Biological Sciences Degree at the University of Parma (1986). Since April 2001 she is a Confirmed Researcher at Parma University (Department of Genetics, Biology of microrganisms, Anthropology and Evolution).
From the beginning of her research carrier, she worked on eukaryotic model-systems to study the interaction between xenobiotic (environmental pollutants, drugs, etc) and the cellular environment. One of the goal of this long-term project was to build up and validate screening systems able to detect different mutagenic events at the molecular level for a quantitative/qualitative evaluation of the 'genetic hazard'
In the medical/oncological research fields she worked on the different tumor specific biochemical/physiological conditions of neoplastic cells, determined especially by the activation of specific DMEs (Drug Metabolizing Enzimes) and mitochondrial activity, defining the major sensitivity of the specific tumor versus the normal cells. On this subject, the key objective of the still ongoing research projects are the characterization of human genes which contribute to individual responsiveness to drugs and the chemical environment.
In recent years, she started new collaborations to identify new therapeutic drugs for treatment of cancers and neglected diseases, in this field she participated at one of the DNDi (Drug for Neglected Disease initiative) international funded program in collaboration with the School of Life Sciences, University of Dundee (UK), the University of Glasgow (UK) and the Swiss Tropical Disease Institute (CH). She worked on the characterization of the structure-activity relationship of newly synthesized drugs on different kind of biological models.
Her most recent research field is the evaluation of novel target therapies, in particular recombinant humanized antibody conjugated with cytotoxic antitumor drugs. A pharmacogenetic approach is performed and different methodologies are employed in order to identify the possible mechanism of drug resistance and to correlate the ex-vivo individual response with clinical outcome.
She is an executive committee member of the Italian Environmental Mutagen Society (SIMA), a member of the EEMS (European Environmental Mutagen Society), the Italian Genetic Association (AGI) and inter-university research consortium on the metal chemistry in biological systems (C.I.R.C.M.S.B.).
Main research interests are: Environmental genotoxicology; Chemoprention; Design of new drugs: characterisation of the structure/cito-and geno-toxic activity; Pharmacogenetics.
Her current research project includes: evaluation of xenobiotic and chemopreventive agents effects in model system; individual susceptibility against xenobiotic and DNA damage, chemotherapy effects by evaluation of DNA damage.
Lunedì dalle 12.00 alle 13.00
Giovedì dalle 12.00 alle 13.00