Stefania Abbruzzetti obtained her degree cum laude (“Volume changes associated to conformational transitions in model poly-peptides prompted by photoinduced pH jumps”) and PhD (“Primary events in protein folding and conformational changes in proteins and model systems studied by fast techniques based on nanosecond pulsed lasers”) in Physics at the University of Parma.
At the University of Parma, she also received a Materials Science and Technology Specialization (50/50 cum laude) in 1998 and a Specialization in Maths and Physics Teaching in 2003.
She has a permanent position as a associate professor in Applied Physics FIS/07 since 2011.
Her degree dissertation won an award from the Italian Society of Pure and Applied Biophysics (SIBPA). She is co-author of a paper that has been selected in the Highlights 2002 of the National Institute of Matter Physics and of a communication, which has been awarded as the best IICVCB2005 poster presentation (Osaka, 2005).
Her research activity is focused on studying photo-activable systems, photochromic proteins for superresolution microscopy, photosensitizers and protein based nanocarriers for applications in photodynamic therapy.
The research activities are conducted in collaboration with many research italian and foreign groups (USA, Germany, UK, Belgium, Spain), which have led to several joint publications. She has participated to several research projects granted by Italian agencies (INFM, CNR, MIUR), and EU agencies.
Her teaching activity at the University (from 1997 to now), University of Parma and Catholic University of Sacro Cuore di Piacenza, includes several courses both of introductory and applied Physics, physics instrumentation and data analysis. She has been supervisor of several students.
The research activity focuses in the development and application of methodologies based on nanosecond pulsed lasers to investigate the protein functional and structural dynamics. She has actively contributed to develop an experimental method to introduce fast changes in proton concentration in solution, using photoactivatable (caged) compounds and nanosecond laser flash photolysis which has allowed to obtain large pH jumps on the nanosecond time scale, stable for several seconds. Another main scientific interest is the use of a photochemical trigger to study the functional dynamics of haemeproteins. Characterization of the functional dynamics of immobilized haemeproteins has been exploited to gain insight into fundamental properties as allosteric mechanisms, ligand migration, structural relaxation and reactivity. Recently, her research activity was focused on the photophysical study of blue light photoreceptors and photosensitizers for singlet oxygen production for photodynamical therapy.
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