Learning objectives
To be able to discuss themechanisms of delivery and expression of the genetic information at molecularlevel.
Prerequisites
<br />It is mandatory to pass the following exams 1)Chemistry and Propaedeutic Biochemistry and 2) Histology before being allowedto take the exam of Biochemistry.
Course unit content
<br />Molecular bases of thehereditary information. Composition and structure of nucleic acids. DNAsynthesis. Telomerases. DNA repair mechanisms and correlations with humanpathologies, cell aging and cancer. RNA: structure, function, transcription, maturation. Definition and propertiesof Genetic Code. Protein synthesis, regulation of gene expression andpost-translational modification of proteins. Signal transduction pathways.Apoptosis. Cell differentiation. Cloning. <br />
Bibliography
<br />Suggestedtextbooks:<br />Baynes JW, Dominiczak MH: Biochimica per le discipline biomediche, secondaedizione, Casa Editrice Ambrosiana, Milano, 2006.<br />Bhagavan NV: Medical Biochemistry, fourth edition,Harcourt/Academic Press, Burlington, 2002.<br />Caldarera CM: Biochimica Sistematica Umana, seconda edizione, CLUEB, Bologna,2003.<br />Devlin TM: Textbook of Biochemistry with clinical correlations, fifth edition,Wiley-Liss, New York, 2002.<br />Garrett RH,Grisham CM: Principi di Biochimica, con messa a fuoco su quella umana, Piccin,Padova, 2004.<br />Mathews CK, van Holde KE, Ahern KG: Biochimica, terza edizione, Casa EditriceAmbrosiana, Milano, 2004.<br />Murray RK, Granner DK, Mayes PA, Rodwell VW; Harper Biochimica, 25a edizione,McGraw-Hill Libri Italia srl, Milano, 2000.<br />Nelson DL, Cox MM: I principi di Biochimica di Lehninger, terza edizione,Zanichelli, Bologna, 2002.<br />Siliprandi N, Tettamanti G: Biochimica Medica: strutturale, metabolica efunzionale, Piccin. Padova, 2005.<br />Voet D, Voet JG: Biochemistry, 3rd edition, John Wiley& Sons, USA, 2004.
Teaching methods
<br />Teachingactivity: frontal lessons, interactive activity for small groups, seminars,learning by solving problems <br />Kindof exam: written + oral test