DRUG RELEASE AND TARGETING
Learning outcomes of the course unit
Release and Targeting of drugs is an advanced course of Pharmaceutical Technology giving the knowledge for the innovative dosage form preparation. Objective of the course is to give to the student the knowledge for designing, developing and manufacturing dosage forms
that for their complexity are sometime called therapeutical system. Together with the essential notions of pharmaceutical technology, the base knowledge of biopharmaceutics, pharmacokinetics and diffusion or mass transport will be given. In addition, the materials, mechanisms and devices adopted in the fundamental operations for the achievement of drug release control and targeting will be treated.
Base pharmaceutical technology knowledge is required.
Course contents summary
- Bioavailability and Bioequivalence
- Administration routes of drugs
- Drug delivery control: story, fundamentals and applications
- Solubility, specific surface area and dissolution rate of drugs and drug
- Mass transport or diffusion: Fick law, thin film diffusion, membrane
transport, free diffusion.
- Natural and synthetic polymers: biodegradable, cellulose derivatives,
PVA, PVC, PEG, PLA, PLGA...
- Devices for drug release control: reservoir and matrix
- Drug carriers:polymer conjugates, micelles, inclusion compounds;
liposomes;micro and nanoparticles;
Administration routes of medicines.
Compartimental pharmacokinteics; Bioavailability and Bioequivalence.
Diffusion: Fick law applied to diffusion in thin layer, through membrane and free diffusion.
Solubility, effective surface area and drug and medicine dissolution rate.
Natural and synthetic polymers.
Modified release of drug: history, fundamental and applications.
Devices for drug release control.
Drug vectors: Liposomes, micro particles and nanoparticles.
P.Colombo, P.L.Catellani, A.Gazzaniga, E.Menegatti, E.Vidale, Principi di tecnologie farmaceutiche. Editore: Casa Editrice Ambrosiana, 2004
A.T. Florence, D.Attwood, Le basi chimico-fisiche della Tecnologia Farmaceutica, EdiSES, Napoli, 2002
The teaching method is frontal didactics. Special care is addressed to the teacher/student interaction. The participation to the lessons is compulsory.
Assessment methods and criteria
The evaluation of the learning will be performed by written tests at the end of each month. The test consists in a free answer question and in
questionaries multiple choice.
The teacher is available for questions on Tueasday, Wednesday and Thursday, before and after the lesson time at 11.00.