RELEASE AND TARGETING OF BIOTECHNOLOGICAL DRUGS
Learning outcomes of the course unit
Release and Targeting of biotec drugs is an advanced course of Pharmaceutical Technology giving the knowledge for the advanced dosage form preparation. Objective of the course is to give to the student the knowledge for designing, developing and manufacturing dosage forms that for their complexity are sometime called colloidal systems
Base pharmaceutical technology knowledge is required.
Course contents summary
Systems for release and targeting of biotec drugs.
Particles and active molecules.
generality; microspheres and microparticles;
phase separation; spray drying;fluid bed;prilling; chemico-physical and biological characterization; in vivo fate.
Pharmaceutical nanoparticles and nanomedicine:
generality; polymeric conjugate; nanospheres and nanoparticles; solid lipid nanoparticles; manufacturing methods: emulsion/solvent evaporation; interfacial deposition; polymerization; jelification; physico-chemical characterization:
Administration route; in vivo fate; targeting concepts:
Tumor therapy: EPR; targeting; iperthermie.
Liposomes and micelles
Preparation and characterization
A.Martin. "Physical Pharmacy" 4th edition, Lea & Febiger, Philadelphia 1993.
S. Benita "Microincapsulation: methods and industrial applications", Marcel Dekker, 1996.
P.Tyle, B. Ram "Targeted therapeutic systems", Marcel Dekker, 1990.
The teaching method is frontal didactics. Special care is addressed to the teacher/student interaction.
Assessment methods and criteria
The evaluation of the learning will be performed by questionaries at the end of the module
The teacher is available for questions on Tueasday, Wednesday and Friday morning and before and after the lesson time.