Learning outcomes of the course unit
Basic knowledge of the mechanisms underlying cell injury and death, tissue response to injury (inflammation, haemostasis, repair), genetic diseases, tumors. Understanding of the essential mechanisms of the immune response and its alterations, with particular reference to applications in transfusion medicine and nursing. Acquisition of terminological competence.
Bases of biology, anatomy, biochemistry and physiology are required.
Course contents summary
The subjects presented in the lectures will be: 1. Cell Death. Oncosis and apoptosis. 2. The blood: composition, cells, general pathophysiology. 3. Inflammation: Events of acute inflammation; The exudate; Types of exudate; Phagocytosis; Chronic inflammation and granulomas; Abscesses and ulcers; Chemical mediators of inflammation; Systemic effects of inflammation; Tissue repair. 4. Haemostasis: Phases and event of the haemostatic response; Hemorrhagic disorders; Thrombosis and embolism; Infarction. 5. Genetic disorders: Mutations; Monogenic diseases: Examples of autosomic dominant, autosomic recessive and X-linked disorders; Multifactorial disorders (malformations, diabetes mellitus); Cytogenetic disorders. 6. Tumors: Classification and nomenclature; Benign and malignant tumors; Tumor etiology; Fundamentals in molecular oncology; Invasivity and metastasis; Pathogenesis of neoplastic diseases. Grading and staging. 7. Innate and adaptive immunity: distinction and cooperation. 8. Antigens and Antibodies. Ag-Ab interaction. Lymphocyte receptors. The Major Histocompatibility Complex (MHC). Processing and presentation of exogenous and endogenous antigens. 9. Functional anatomy of the immune response. Lymphocyte activation and effector functions. Primary and secondary reaction. Principles of vaccination. Immune response to infections. 10. Hypersensitivity. Primary and secondary immunodeficencies. HIV infection. 11. Blood groups. AB0 system. Rh system. Other blood groups. Hemolytic disease of the newborn. Fundamentals of transfusional practice. Transfusional complications.
Maier e Mariotti. Elementi di Patologia Generale e Fisiopatologia. McGrawHill, Milan, 2009.
Most of the subjects treated in the lessons are included in this textbook (except immunohematology; for this subject, learning material will be provided duringg the lectures.da edizione. Masson Editore
- Vera Del Gobbo "Immunologia per le lauree sanitarie" terza edizione. Piccin Editore
- F. Licastro & M. Chiappelli "Quick Review: Immunologia" EdiSES Editore
Interactive oral lessons. Visual tutorials will support oral lessons. This material will be availble to students at the end of the course.
Assessment methods and criteria
Oral examination with a previous, facultative multiple-choice test.