METALS IN MEDICINE

Metals in medicine: a historical perspective. General requirements, structure-activity relationships and clinical studies of metalloparmaceuticals. Target of metalloparmaceuticals and reactions of metal complexes in biological systems. Diagnostics: the role of metalsin the anatomical and functional imaging . Human therapy: Chelation (sequestration of metals, macrocyclic antibiotics, metal poisoning, thalassemia and iron, copper and Wilson's disease and Alzheimer's disease); metal complexes in cancer therapy (compounds of platinum, palladium and non-cisplatin-like); gold in the treatment of rheumatoid arthritis; vanadium and diabetes. Radiopharmaceutical therapy and nanomedicine.