METALS IN MEDICINE
Learning outcomes of the course unit
The course aims to provide students with basic notions of Inorganic Pharmaceuticals.
Course contents summary
Metals in medicine: a historical perspective. General requirements, structure-activity relationships and clinical studies of metalloparmaceuticals. Target of metalloparmaceuticals and reactions of metal complexes in biological systems. Diagnostics: the role of metalsin the anatomical and functional imaging . Human therapy: Chelation (sequestration of metals, macrocyclic antibiotics, metal poisoning, thalassemia and iron, copper and Wilson's disease and Alzheimer's disease); metal complexes in cancer therapy (compounds of platinum, palladium and non-cisplatin-like); gold in the treatment of rheumatoid arthritis; vanadium and diabetes. Radiopharmaceutical therapy and nanomedicine.
Chris Jones, John Thornback, Medicinal Applications of Coordination Chemistry, RSC Publishing, 2007.
James C. Dabrowiak, Metals in Medicine, Wiley, 2009.
Marcel Gielen, Edward R.T. Tiekink, Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine, Wiley, 2005.
Assessment methods and criteria