To provide basic information and specific application examples on one of the most advanced fields of post-genomic research, with special reference to the new frontiers of molecular pharmacology and toxicology, “systems biology” and other modern applications of biotechnology to drug discovery.
Course contents summary
-Basic knowledge of chemistry, biochemistry, molecular biology and genomics and pharmaceutical chemistry
-Goals and fields of application of chemogenomics
- Chemogenomics applied to “drug discovery”, “target/mode of action identification” and “drug validation”
-Chemogenomic technologies in the yeast S. cerevisiae: microarrays and the “compendium” approach; yeast two-hybrid and its variants; the yeast gene deletion mutant collections
-“Genomic phenotyping” of small-molecule drugs (or toxicants) in yeast
-Mechanism of action, off-target effects and new applications for “old drugs” or “lead compounds” discarded in advanced phase of (pre)clinical development
-New drugs and bioactive compounds of molecular-biological origin: nucleotide and peptide aptamers, interfering RNAs
-Drugs and vaccines based on recombinant proteins/peptides
-Analyses of the goals, strategies and results of specific start-ups in the field of chemogenomics
Reviews, selected articles and powerpoint presentations from leading companies in the field of Chemogenomics, which will be made available to the students in an electronic format.