GENERAL AND CLINICAL PATHOLOGY
cod. 16333

Academic year 2007/08
2° year of course - Second semester
Professor responsible for the course unit
DALL'ASTA Valeria
integrated course unit
4 credits
hub:
course unit
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Course unit structured in the following modules:

Learning objectives

<br />At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism. Moreover the studet should  know the most relevant laboratory tests, understand the role and the importance of the laboratory medicine for a correct diagnosis and  evaluate cost/benefit ratio.<br /> 

Prerequisites

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Course unit content

<br />Oncology. Definitions, nomenclature, epidemiology. Tumor etiology: Chemical carcinogenesis; Radiation cancerogenesis; Heredity and tumors. The cell cycle: control mechanisms and their alterations. Stem cells and cancer. Protooncogenes, oncogenes and oncoproteins. Oncosuppressor genes and their products. Altered DNA repair mechanisms and tumors. Defects of apoptosis and cancer. Intiation and promotion. The neoplastic cell. Tumor progression. Tumor angiogenesis. <br />Invasivity. Metastasis.<br /> <br />Metabolic disorders: Disorders of lipid metabolism; Disorders of carbohydrate metabolism: metabolic alterations in diabetes; Pathophysiology of blood and disorders of hemopoiesis. <br />Clinical pathology: general principles. The interpretation of laboratory tests. The patient preparation. The biological samples. Full blood count. Coagulation. Glucose metabolism.  Lipids and lipoproteins.  Plasma proteins. Diagnostic enzimology and other biochemical markers of organe damage.  Nitrogen metabolites and renal function. Electrolytes.  Hormones. Tumour markers.  Urine analysis.

Full programme

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Bibliography

<br />Kumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. 7th Edition, Elsevier, 2005<br />G. Federici, P. Cipriani, C. Cortese, A. Fusco, P. Ialongo, C. Milani: Medicina di laboratorio – McGraw - Hill (ultima edizione)<br /> <br />Widmann: Interpretazione clinica degli esami di laboratorio – McGraw - Hill (ultima edizione)<br /> 

Teaching methods

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Assessment methods and criteria

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Other information

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