Learning outcomes of the course unit
Structure and function of nucleic acids, proteins, carbohydrates and lipids. Foundations of Metabolic Pathways.
Course contents summary
A) Organic chemistry foundations.
B) STRUCTURAL BIOCHEMISTRY
Nucleotides and nucleic acids. Nucleotides chemistry and nucleic acids structures. Biological role of DNA, tRNAs, mRNA, and ribosomal RNA.
Aminoacids, peptides and proteins. Amino Acids classification; the peptide bond. The covalent structure of proteins: overview of protein structure. Protein folding and protein functions.
Hemoglobin: structure and function. Oxygen binding and transport at the molecular level. Factors affecting oxygen affinity.
How Enzymes work. Classification of enzymes.
Lipids. Classification, structure and functions of fatty acids, triglycerides and cholesterol. Structural lipids in membranes.
Carbohydrates. Structure and classification of monosaccharides and disaccharides and polysaccharides.
C) METABOLIC BIOCHEMISTRY
Free Energy and spontaneous reactions. Thermodynamics of biological reactions, ATP as energy carrier.
Cellular metabolism. Oxidation and degradation reactions, biosynthetic reactions.
Mitochondrial reactions. Coenzymes and biological redox reactions. Electron-transfer reactions in mitochondria: components and functions. ATP synthesis. Regulation of Oxidative Phosphorylation.
Glycolysis, Gluconeogenesis, The Citric Acid Cycle. Glycogen metabolism.
Fatty acids and aminoacids metabolism.
Integration and Hormonal Regulation. Insulin and glucagon. Liver, muscle and brain metabolism.
Le basi della biochimica
Champe Pamela C. - Harvey Richard - Ferrier Denise R.
Frontal lessons aided by presentations. Oral exam.