Learning outcomes of the course unit
To provide the bases for the comprehension of biologic propertes of tumors and the molecular basis of carcinogenesis.
Course contents summary
Cancer stem cells and cancer cell lineages
Molecular basis of cancer:
Essential alterations for malignant transformation
Self-sufficiency in growth signals: oncogenes
Insensitivity to growth inibition and escape from senescence: tumor suppressor genes
Evasion from apoptosis
Invasion and metastasis
No specific text is adopted. Proper reference to the texts of biochemistry and cell biology used in previous courses is recommended. Lectures will be supported by slides and scientific literature, which will be provided to the students.
Oral lessons (slides and scientific literature will be used during the lessons) .
The tutorials will be provided to the students.