Learning outcomes of the course unit
To teach biochemical and molecular biology methodologies applied to theinvestigation of structure, dynamics and function of biologicalmacromolecules.
To teach cellular biochemistry, mechanisms ofsignal transduction, interaction between proteins and DNA and betweendrugs and biomolecules.
To teach modern biotechnological and computational strategies for the development of drugs
Course contents summary
Use of PC in biochemistry: hardware and software.
Biobliographic search and database
Methods for protein purification, isolation and characterization
Excitable membrane and sensor systems
Receptors, cytochines, growth factors and differentiation
Intra and intercellular communications
Drug-protein and drug-DNA recognition
Biotechnology for the development and production of drugs
Genomics and Proteomics
Structure-based and computer-assisted drug design
Stryer, Biochemistry, Zanichelli, V ed.
Wilson, Biochemical methodology, Cortina
Alberts et al., Molecular Cell Biology, Zanichelli
Darnell et al., Molecular Cell Biology, Zanichelli
Crommelin and Sindelar, Pharmaceutical biotechnology, Zanichelli
Reed et al., Basic methodologies for biomolecular sciences, Zanichelli
Ninfa and Ballou, Basic methodologies for biochemistry and biotechnology, Zanichelli
All suggested texts are translations from English written books available at the corresponding publishing companies
The course consists in oral lectures using overheadtransparences on the different topics of the course, withintegration from recently published scientific papers, that are provided on line at the Department web page.
The oral exam is onall topics of the course, eventually integrated by a subject of the course selected and more deeplystudied by the candidate.