HUMAN AND MODEL ORGANISMS MOLECULAR GENETICS GENOTOXICITY
Learning outcomes of the course unit
Aims of the course is the study of genetic approaches applied to genomics and functional analysis in eukaryotes. Particular attentions will be paied to yeast, a model organism in fundamental and biotechnologic applications.
Course contents summary
YEAST AS MODEL ORGANISM
Forward e reverse genetics- Genome sequencing in S. cerevisiae- Comparative genomics in yeasts- S. cerevisiae deletant collection and use of null mutants in functional analysis- Methods for gene interaction studies applied to human diseases - Yest as model organism for the study of mitochondrial genetics- Yeast as model organism for the study of mitochondrial diseases.
FUNCTIONAL ANALYSIS IN PLANTS
Caenorhabditis elegans AS MODEL ORGANISM
Forward e reverse genetics in C. elegans. Functional analysis by RNAi - C. elegans as model organism for the study of human pathologies.
Original papers selected by the teacher