Learning outcomes of the course unit
To bring mechanisms and nature of toxic effects of drugs and xenobiotics to student's knowledge.
It is necessary to pass the Pharmacology examination.
Course contents summary
-First principles of toxicity
-Experimental toxicology, evaluation of toxicological risks, mechanisms and tests of toxicity
-ADME of toxic substance
-Metabolism of xenobiotics
-Cancerogenesis, teratogenesis and mutagenesis
-Idiosincrasic and allergic reactions. Interactions between xenobiotics
-Metals, Solvents, Pesticides, IPA, PCOD, PCB
-Toxicology of biotecnological products
- Poisons and antidotes
-Central Nervous Sistem (CNS)
· General principles of toxicology.
· Mechanisms of toxicity. Toxicity test.
· Absorption, distribution and excretion of toxic substances.
· Biotransformation of xenobiotics.
· Carcinogenesis, teratogenesis, mutagenesis.
· Experimental toxicology and toxicological risk assessment.
· Idiosyncratic reactions and allergic diseases, interactions between xenobiotics.
· Toxicology of pesticides, metals, solvents, pesticides, PAHs, PCOD, PCB, plant and animal toxins.
· Environmental Toxicology: air pollution, water and soil.
· Toxicology food and nutrition: Food Additives and Contaminants. Regulatory bodies.
· Occupational Toxicology
· Toxicology of biotechnology products.
· Toxicology of principal organs.
-ERNEST HODGSON: “Tossicologia Moderna”, EdiSES
-CASARETT & DOULL’S: "Tossicologia: fondamenti dell’azione delle sostanze tossiche", Ed. EMSI,
-W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.
-C.L. GALLI, E. CORSINI, M. MARINOVICH “Tossicologia”, Piccin
Assessment methods and criteria