Learning outcomes of the course unit
- To provide knowledge and understanding of the mechanism of action and of pharmacokinetic properties of drugs, with particular reference to compounds of radiodiagnostic and radiotherapeutic interest.
- To provide knowledge and understanding of the molecular targets of drugs and of the processes involved in cell labeling by radionuclides.
- To To provide a general description of the production and storing of radionuclides and their use in radiodiagnostics
Course contents summary
General principles: Definition and characteristics of drugs: Therapeutic and diagnostic use of drugs. Radiolabeled compounds.
Pharmacokinetics. The movements of drugs into the organism: cellular basis of pharmacokinetics. Main processes that control the plasmatic levels of drugs: absorbtion, distribution, biotransformation and excretion. Bioavailability and drug accumulation in tissues. Routes of drug administration.
Mechanism of drug action. Chemicophysical interactions of drugs with living cells: Regulatory proteins and their involvement in drug action. Receptors: structure and functions. Type of receptors and post-receptor events. Interaction of drugs with enzymes, carriers and DNA.
Radiolabeled compounds of pharmacological interest. Synthesis, production and stability of radiolabeled drugs: technetium, iodinated moyeties and other radionuclides. Interaction of radionuclides with the living cells: tissue labeling. Application of radionuclides in the clinical practice: use in radioimaging and radiotherapy.
'Farmacologia Generale e Molecolare', 3rd Ed., F. Clementi, G. Fumagalli, UTET, Torino, (2004).