GENERAL PATHOLOGY
cod. 00768

Academic year 2009/10
2° year of course - First semester
Professor
Academic discipline
Patologia generale (MED/04)
Field
Discipline mediche di rilevanza odontoiatrica
Type of training activity
Characterising
40 hours
of face-to-face activities
4 credits
hub: -
course unit
in - - -

Integrated course unit module: GENERAL AND CLINICAL PATHOLOGY (ATT)

Learning objectives

At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism).

Prerequisites

At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism). 9. Prerequisiti: NO 10. Contenuti del corso: <br />
Introductory concepts. Health and homeostasis. Deviations from homeostasis. The etiology of tissue injury at molecular level. Extrinsic causes of disease: Physical causes; Chemical causes; Biological causes. Intrinsic causes of disease: Single-gene disorders with classic and non classic inheritance; Multifactorial diseases; Cytogenetic disorders <br />
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Course unit content

 Introductory concepts. Health and homeostasis. Deviations from homeostasis. The etiology of tissue injury at molecular level. Extrinsic causes of disease: Physical causes; Chemical causes; Biological causes. Intrinsic causes of disease: Single-gene disorders with classic and non classic inheritance; Multifactorial diseases; Cytogenetic disorders <br />
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Pathophysiology of tissue injury and repair. The response to tissue injury. Hemostasis: Phases and mechanisms; Hemorrhagic diseases due do defects in primary or secondary hemostasis; Consumption coagulopathies. Thrombosis, embolism, infarction. Acute and chronic inflammation; Events, mechanisms, types and evolution of the inflammatory process; Chemical mediators of inflammation; Types of inflammatory lesions; Systemic effects of inflammation. Tissue repair and regeneration: Stem cells and tissue regeneration; Tissue repair and its alterations; Wound healing; Fibrosis. Atherosclerosis. <br />
The immune response. The Major Hystocompatibility Complex; Innate immunity: Phagocitosis; Complement activation. Specific Immunity: Cell-mediated Immunity; Humoral Immunity. <br />
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Cellular pathology. Reversibile and irreversibile cell injury. Adaptive mechanisms to cell injury: hypertrophy, hyperplasia, atrophy, metaplasia, dysplasia. The ischemic-hypoxic stress: Mechanisms; Metabolic consequences; Reperfusion injury; Cell death: necrosis and apoptosis

Full programme

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Bibliography

Kumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. 7th Edition, Elsevier, 2005

Teaching methods

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Assessment methods and criteria

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Other information

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