GENERAL AND CLINICAL PATHOLOGY (ATT)
cod. 16315

Academic year 2009/10
2° year of course - First semester
Professor responsible for the course unit
DALL'ASTA Valeria
integrated course unit
4 credits
hub:
course unit
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Course unit structured in the following modules:

Learning objectives

<br />At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism).

Prerequisites

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Course unit content

<br />Introductory concepts. Health and homeostasis. Deviations from homeostasis. The etiology of tissue injury at molecular level. Extrinsic causes of disease: Physical causes; Chemical causes; Biological causes. Intrinsic causes of disease: Single-gene disorders with classic and non classic inheritance; Multifactorial diseases; Cytogenetic disorders<br /><br />Pathophysiology of tissue injury and repair. The response to tissue injury. Hemostasis: Phases and mechanisms; Hemorrhagic diseases due do defects in primary or secondary hemostasis; Consumption coagulopathies. Thrombosis, embolism, infarction. Acute and chronic inflammation; Events, mechanisms, types and evolution of the inflammatory process; Chemical mediators of inflammation; Types of inflammatory lesions; Systemic effects of inflammation. Tissue repair and regeneration: Stem cells and tissue regeneration; Tissue repair and its alterations; Wound healing; Fibrosis. Atherosclerosis.<br /> The immune response. The Major Hystocompatibility Complex; Innate immunity: Phagocitosis; Complement activation. Specific Immunity: Cell-mediated Immunity; Humoral Immunity.<br /><br />Cellular pathology. Reversibile and irreversibile cell injury. Adaptive mechanisms to cell injury: hypertrophy, hyperplasia, atrophy, metaplasia, dysplasia. The ischemic-hypoxic stress: Mechanisms; Metabolic consequences; Reperfusion injury; Cell death: necrosis and apoptosis

Full programme

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Bibliography

Kumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. 7th Edition, Elsevier, 2005

Teaching methods

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Assessment methods and criteria

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Other information

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