Learning outcomes of the course unit
At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism).
Course contents summary
Oncology. Definitions, nomenclature, epidemiology. Tumor etiology: Chemical carcinogenesis; Radiation cancerogenesis; Heredity and tumors. The cell cycle: control mechanisms and their alterations. Stem cells and cancer. Protooncogenes, oncogenes and oncoproteins. Oncosuppressor genes and their products. Altered DNA repair mechanisms and tumors. Defects of apoptosis and cancer. Intiation and promotion. The neoplastic cell. Tumor progression. Tumor angiogenesis. Invasivity. Metastasis.
Metabolic disorders: Disorders of lipid metabolism; Disorders of carbohydrate metabolism: metabolic alterations in diabetes; Pathophysiology of blood and disorders of hemopoiesis.
Kumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. 7th Edition, Elsevier, 2005