GENERAL AND CLINICAL PATHOLOGY
Learning outcomes of the course unit
At the end of the course, the student should have attained in depth knowledge of the etio-pathogenetic factors that underlie the alterations of structures, functions and mechanisms of control and response to tissue damage at different levels of integration (molecules, cells, tissues, organism. Moreover the studet should know the most relevant laboratory tests, understand the role and the importance of the laboratory medicine for a correct diagnosis and evaluate cost/benefit ratio.
Course contents summary
Oncology. Definitions, nomenclature, epidemiology. Tumor etiology: Chemical carcinogenesis; Radiation cancerogenesis; Heredity and tumors. The cell cycle: control mechanisms and their alterations. Stem cells and cancer. Protooncogenes, oncogenes and oncoproteins. Oncosuppressor genes and their products. Altered DNA repair mechanisms and tumors. Defects of apoptosis and cancer. Intiation and promotion. The neoplastic cell. Tumor progression. Tumor angiogenesis.
Metabolic disorders: Disorders of lipid metabolism; Disorders of carbohydrate metabolism: metabolic alterations in diabetes; Pathophysiology of blood and disorders of hemopoiesis.
Clinical pathology: general principles. The interpretation of laboratory tests. The patient preparation. The biological samples. Full blood count. Coagulation. Glucose metabolism. Lipids and lipoproteins. Plasma proteins. Diagnostic enzimology and other biochemical markers of organe damage. Nitrogen metabolites and renal function. Electrolytes. Hormones. Tumour markers. Urine analysis.
Kumar, Abbas, Fausto. Robbins and Cotran Pathologic Basis of Disease. 7th Edition, Elsevier, 2005
G. Federici, P. Cipriani, C. Cortese, A. Fusco, P. Ialongo, C. Milani: Medicina di laboratorio – McGraw - Hill (ultima edizione)
Widmann: Interpretazione clinica degli esami di laboratorio – McGraw - Hill (ultima edizione)