GENERAL PATHOLOGY
Learning outcomes of the course unit
In the context of the integrated course, the course is proposed to supply to the students general concepts on the causes and the mechanisms that carry to the diseases. In particular, general knowledge about the chemical and physical causes of diseases and concepts of cellular pathology will be supply. More particularly, the student will have to acquire knowledge about inflammation, neoplasia, genetic diseases, genetic deafness, diabetes, atherosclerosis, diseases of the blood and alterations of the haemostasis
Prerequisites
It is advised to have supported the examinations of the previous year
Course contents summary
Concepts of aetiology and pathogenesis
Chemical and physical causes of diseases
Genetic damage. Mutations.
Hereditary diseases
Modality of transmission of the pathological characters.
Monogenic hereditary diseases: examples.
Hereditary deafness
Multifactorial inheritance
Chromosomic aberrations
Concepts and mechanisms of cellular pathology
Reversible and irreversible cellular damage.
Necrosis and apoptosis
Ischemic damage
Inflammation
Signs and phenomena of the acute inflammation
Inflammatory exudates
Phagocytoses
Chemical inflammatory mediators
Chronic inflammation
The fever
Alterations in the proliferative state
Cell cycle
Hypertrophy
Hyperplasia
Neoplasia
Nomenclature
Epidemiologia
Grading and staging
Differences between benign and malignant tumors
Neoplastic progression
Molecular bases of the neoplasie
Metastasis
Physiopatology of the blood and the haemostasis
Constitution of the blood
Emopoiesi
Anemias
Haemostasis and its alterations
Diabetes
Arterial hypertension
Atherosclerosis
Recommended readings
One text chosen between the following:
1. Spector e Axford, Introduzione alla Patologia Generale, CEA
2. Woolf, Patologia Generale – Meccanismi della malattia, Idelson-Gnocchi
Teaching methods
Frontal lesson with the use of supports audiovisual, argument in classroom with the students, supply of the audiovisual aids, talks with the student upon request.
The final appraisal involves one oral verification according to the calendar of examination of the Integrated Course.
