MEDICAL GENETICS

Mitotis, meiosis. Principles of mendelian inheritance (Mendel’s laws), physical basis of mendelian inheritance, expression and interaction of genes, crossing over and linkage, mapping, biochemical nature of genetic material, replication and repair of DNA, the genetic code, the “central dogma” of molecular genetics, mutation. Mitochondrial heredity. Polymorphisms, multiple alleles (ABO and MHC systems). Mechanisms of genetic transmission in humans. Gene structure and function. Mechanisms of gene regulation in prokaryotes (the operon model) and eukaryotes. Human cytogenetics and chromosomal abnormalities. Polygenic  inheritance. Principles of population genetics. Principles of genetic manipulation and recent developments in molecular genetics diagnosis of diseases.