CLINICAL BIOCHEMISTRY CLINICAL MOLECULAR BIOLOGY
Learning outcomes of the course unit
This course aims to provide the informations and the scientific background to approach correctly the practical aspects in Clinical Biochemistry (also out of conventional laboratories) to figure out the complexity concerning the biological samples and the possible sources of error, with respect to analysis in the sport ambit aiming the prevention of illicit expedients. Moreover, this earlier knowledge sets up the cultural bases in the further study of the “Medicina di laboratorio applicata alle scienze motorie” (Laboratory medicine applied to sport sciences) where the attention is mainly on the athlete health and the role of clinical biochemistry in the monitoring of training
There are no obligatory prerequisites, but these topics of clinical biochemistry are part of an interdisciplinary science, the student needs the basic knowledge in biology, anatomy, physiology, chemistry and biochemistry
Course contents summary
Laboratory medicine with regard to sport doping prevention. Laboratory tests: definition, typology, request modality. Biological sample: properties and characteristics. Pre-analytical and analytical variabilities affecting the laboratory data. Strategy about laboratory investigation of prohibited substances or methods: direct detection or recognition of biochemical alteration induced on the metabolisms.
Current waived test. Point of care testing (POCT): use and application. Criteria for test waiving. Quality control in POCT. Implementation and monitoring of POCT. Specimen and its treatment in POCT.
Analytical basic principles of prohibited substances belonging to the following classes: stimulants, narcotics, diuretics, peptide hormones, anti-estrogens, masking tools. Analytical basic principles to investigate the following prohibited methods: haematic doping, chemical or physical or pharmacological manipulation, genetic doping.
S.D.Ferrara. Doping Antidoping -Piccin
L. Spandrio: Biochimica Clinica. Ed. Sorbona, Milano.
There are no obligatory prerequisites, but these topics of Clinical Biochemistry are part of an interdisciplinary science, the student needs the basic knowledge in Biology, Anatomy, Physiology, Chemistry and Biochemistry