Learning outcomes of the course unit
Themodules ha as its aspective to provide students with basis knowledge insome aspects of clinical biochemistry to improve their cultural andprofessional formation
Course contents summary
Oxygen transport - Structureandfunctionof mioglobin and hemoglobin. Oxygen transport intheblood.Hemoglobinopathies. Catabolism of heme. Formation ofbilepigments.Metabolism of bilirubin in intestine. Hyperbilirubinemia.<>Blood coagulation - PlateletactivationandWillebrand Factor (vWF). Description of clottingcascade.Intrinsicclotting cascade. Extrinsic clotting cascade.Activation ofthrombin.Regulation thrombin levels. Activation offibrin. Dissolutionof fibrinclots. Clinical significances ofhemostasis: the bleedingdisorders.
Signal transduction-Aspects of cellular signalling.Extracellular signals:hormones,cytokines. Detection of extracellularsignals: intracellularandextracellular receptors. Proteinphosphorilation, kinasesandphosphatases. cAMP, adenylyc cyclase andth role of G proteins.Inositolphosphate metabolism and the roles ofother membranelipids.Intracellular calcium: its control and role asan intracellularsignal.Nitric oxide.
frontal lessons with slides