Learning objectives
Themodules ha as its aspective to provide students with basis knowledge insome aspects of clinical biochemistry to improve their cultural andprofessional formation<br />
Course unit content
<br />Oxygen transport - Structureandfunctionof mioglobin and hemoglobin. Oxygen transport intheblood.Hemoglobinopathies. Catabolism of heme. Formation ofbilepigments.Metabolism of bilirubin in intestine. Hyperbilirubinemia.<>Blood coagulation - PlateletactivationandWillebrand Factor (vWF). Description of clottingcascade.Intrinsicclotting cascade. Extrinsic clotting cascade.Activation ofthrombin.Regulation thrombin levels. Activation offibrin. Dissolutionof fibrinclots. Clinical significances ofhemostasis: the bleedingdisorders.<br /><br />Signal transduction-Aspects of cellular signalling.Extracellular signals:hormones,cytokines. Detection of extracellularsignals: intracellularandextracellular receptors. Proteinphosphorilation, kinasesandphosphatases. cAMP, adenylyc cyclase andth role of G proteins.Inositolphosphate metabolism and the roles ofother membranelipids.Intracellular calcium: its control and role asan intracellularsignal.Nitric oxide.<br />
Teaching methods
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frontal lessons with slides<br />
oral exposition