BIOCHEMISTRY
cod. 08699

Academic year 2008/09
2° year of course - First semester
Professor
Academic discipline
Biochimica (BIO/10)
Field
Scienze biomediche
Type of training activity
Basic
20 hours
of face-to-face activities
1 credits
hub: -
course unit
in - - -

Integrated course unit module: PATHOLOGY

Learning objectives

Themodules ha as its aspective to provide students with basis knowledge insome aspects of clinical biochemistry to improve their cultural andprofessional formation<br />

Prerequisites

none

Course unit content

<br />Oxygen transport - Structureandfunctionof mioglobin and hemoglobin. Oxygen transport intheblood.Hemoglobinopathies. Catabolism of heme. Formation ofbilepigments.Metabolism of bilirubin in intestine. Hyperbilirubinemia.<>Blood coagulation - PlateletactivationandWillebrand Factor (vWF). Description of clottingcascade.Intrinsicclotting cascade. Extrinsic clotting cascade.Activation ofthrombin.Regulation thrombin levels. Activation offibrin. Dissolutionof fibrinclots. Clinical significances ofhemostasis: the bleedingdisorders.<br /><br />Signal transduction-Aspects of cellular signalling.Extracellular signals:hormones,cytokines. Detection of extracellularsignals: intracellularandextracellular receptors. Proteinphosphorilation, kinasesandphosphatases. cAMP, adenylyc cyclase andth role of G proteins.Inositolphosphate metabolism and the roles ofother membranelipids.Intracellular calcium: its control and role asan intracellularsignal.Nitric oxide.<br />

Full programme

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Bibliography

<br />Teacher notes

Teaching methods

<br />
frontal lessons with slides<br />
oral exposition

Assessment methods and criteria

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Other information

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