OSTEOGENESIS AND CONDROGENESIS: MODELS OF BIOCOMPATILITY IN VIVO AND IN
Learning outcomes of the course unit
The aim of the course is to review fundamentals and provide an up-to-date account of current knowledge in biology and pathophysiology of articular cartilage tissue focusing on the cartilage repairing. With a practical approach during the lab classes the students will acquire a core professional training in primary cell culture methods and techniques and also they will acquire capacity to apply systems to culture articular chondrocytes and to maintain chondrocyte differentiation.
Course contents summary
Osteochondrogenesi (Module A)
Lecturer: Prof. Paolo Borghetti (VET/03)
(CFU: 1 CFU lesson (8 hours) + 1 CFU praticals (8 hours)
Anatomy , histology and biomechanics of articular joints. Structure, biology and metabolism of the articular cartilage.
Physiopathology of the tissue cartilage metabolism. The molecular basis of chondrocyte differentiaiton and chondrogenesis. Biomaterials for cartilage reparing
Isolation of chondrocytes from articular cartilage tissue.
Adhesion and tridimensional models of primary chondrocyte culture.
Tecnique for the maintainance of the differentiation of articular chondrocytes in culture.
1) Scientific reviews on course topics
2) Lab experimental protocols