LABORATORY OF ORGANIC CHEMISTRY I
Learning outcomes of the course unit
The objective of the course is to give the tools to perform simple laboratory operations and to become familiar with the most common organic compound purification and characterisation techniques; a further objective is to train the student to the effectuation of simple organic reactions.
The arguments Knowledge of developed in the General and Inorganic Chemistry course and in Organic Chemistry course.
Course contents summary
Programma: The organic chemistry laboratory: safety regulations; laboratory equipment: risks and use; laboratory solvents, industrial solvents and their use. Spectroscopy techniques (NMR, FT-IR, UV-Vis) and Mass Spectrometry: basic concepts; examples of structural determination through the NMR spectroscopy. Laboratory separation techniques: purification of solids and purity criteria; the solvent choice e the melting point determination; extraction techniques of organic compounds; natural product extraction; basic and acid substances extraction; chromatographic separations; the choice of the eluant, thin layer chromatography, column chromatography, gas chromatography; distillation techniques: simple distillation and fractional distillation. Laboratory experiences: organic compound purification through recrystallisation; caffeine extraction from tea leaves; organic product separation through acid-base extraction; ethyl acetate and butyl acetate separation through fractional distillation and gas-chromatographic analysis. Thin layer chromatography, spinach extract separation on column chromatography: spectrophotometric UV-Vis analyses; alkane chlorination: chemical assays and gas chromatographic analyses; Friedel-Crafts acylation and product analysis through NMR spectroscopy; analysis through chemical assays.
R.M. ROBERTS, J.C. GILBERT, L.B. RODEWALD, A.S.
WINGROVE Chimica Organica
M.D'ISCHIA- Chimica Organica Sperimentale--PICCIN
R.M. Silverstein, F.X. Webster, 'Identificazione Spettroscopica di Composti Organici' Casa Editrice Ambrosiana
FRONTAL LESSONS AND NMR EXERCISES - 30 ORE
NINE LABORATORY EXPERIENCES, EACH FOUR HOURS