GENETICS AND MUTAGENESIS
Learning outcomes of the course unit
To provide bases of genetics in the context of environmental mutagenesis
Course contents summary
Part 1 - DNA and mutations
- DNA structure, Watson and Crick model
- DNA replication
- Causes of genetic instability of DNA
- Spontaneous mutations
- Mechanisms
- Induced mutations and causes
- Mutagens and mechanisms
- Mutations and mutants
- Relationships among genotype and phenotype
Part 2 - Mutagenesis tests
- Mutagens and environmental mutagens
- Mutagenesis tests: definitions, uses, principles
- Mutagenesis tests with microbes, cells, animals, plants
- Mutagenesis tests and genetic diseases in man
- Mutagenesis tests and relationships with carcinogenesis and teratogenesis tests
Part 3 - Hypersensitivity to environmental pollutants
- Modes of exposure
- Exposure biomarkers
- Effect biomarkers
- Susceptibility biomarkers (hypersensitivity)
- Ecogenetic markers
- Correlations among biomarkers
Recommended readings
*Genetica biochimica umana. - Harris, Harry Bologna : Zanichelli, 1972, c1974. - ix, 324 p. ; 24 cm. ((Tit. orig.: The principles of human biochemical genetics
*Ecogenetics : genetic predisposition to the toxic effects of chemicals / editor-in-chief Philippe Grandjean ; editorial board Dinko Kello ... et al.!. - London etc.! : Chapman and Hall, 1991. - XIV, 288 p. ; 24 cm.
*Test di mutagenesi. - Padova : Piccin, 1978. - 3 v. ; 20 cm.
*Batteri, lieviti, attivazione metabolica in vitro / Roberto Barale, Angelo Abbondandolo. - Padova : Piccin, 1978. - 62 p. : ill. ; 24 cm.
*Funghi filamentosi, piante, insetti, cellule di mammifero in vitro / Stefania Bonatti, Roberto Barale, Angelo Abbondandolo. - Padova : Piccin, 1978. - 68 p. : ill. ; 24 cm.
*Uomo, animali da laboratorio / Angelo Abbondandolo. - Padova : Piccin, 1978. - 40 p. : ill. ; 24 cm.
*Mutagenesi ambientale / di Nicola Loprieno. - 2. ed. - Padova : Piccin editore, c1979. - 102 p. ; 24 cm.
