ENVIRONMENTAL MUTAGENESIS
cod. 07948

Academic year 2009/10
3° year of course - Second semester
Professor
Academic discipline
Genetica (BIO/18)
Field
A scelta dello studente
Type of training activity
Student's choice
24 hours
of face-to-face activities
3 credits
hub:
course unit
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Learning objectives

<br />Aim of the course is to provide a panoramic view of the various aspect of the environmental mutagenesis and in particular of the environmental genotoxic risk at which human and animals are subjected.  The course provides a detailed overview of methodologies for monitoring human populations for signs of exposure to genotoxic agents, and monitoring the environment itself (e.g., air, water, soil).

Prerequisites

<br />
Basic knowledge of Genetics, Biochemistry and Molecular Biology

Course unit content

<br />Molecular basis of DNA alterations<br /><br /> spontaneous alterations of and damages to DNA<br /> chemical and physical mutagens<br />molecular mechanisms of mutagenesis<br />Molecular mechanisms involved in the control of genome integrity<br /><br />metabolism of xenobiotics <br />DNA repair in prokaryotic and eukariotic organisms<br />Mutations in somatic cells <br /><br /> mutagenesis and cancerogenesis<br />Mutations in germ cells<br />Sources of genotoxic pollutants<br /><br /> natural and manmade mutagens and cancerogens in: environmental samples (air, soil, water, etc.) and diet<br />Mutagenicity testing<br /><br /> biomarkers <br /> methods and testing strategies: in vitro and in vivo mutagenicity tests.<br />Protocols for genotoxins assessment<br /><br /> environmental mixtures and biological samples <br /> guidelines for mutagenicity testing and risk assessment.

Full programme

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Bibliography

Mutagenesi ambientale a cura di Lucia Migliore Ed. Zanichelli 2004, ISBN 8808-07719-5. <br />Tossicologia a cura di Greim H. e Deml E., Ed. Zanichelli 2000, ISBN 8808-09979-2.

Teaching methods

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Assessment methods and criteria

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Other information

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