Course aims: To provide the students the basic knowledge on functional and defensive role of the inflammatory process, on its cellular and molecular regulation and its evolutive aspects; the students will achieve the fundamental concepts on pathogenesis of immune-mediated diseases (hypersensitivity, autoimmunity and immunosuppression).
Course contents summary
CONTENT OF THE MODULE OF GENERAL PATHOLOGY AND IMMUNOLOGY II
(3 CFU: 24 hours) (Lecturer : Prof. Paolo Borghetti)
The response to cell damage: inflammation
- General features, ethiology and evolutive aspects of inflammation
- Dynamics and regulation of acute and chronic inflammation.
- Different types of acute and chronic inflammation
- Innate immunity : cellular (phagocytosis and cytotoxicity) and humoral (complement) defensive responses
- Systemic effects of inflammation.
Basic Concepts of immunopathology
- Types of hypersensitivity (type I, II, III, IV)
- Tolerance and autoimmunity : main pathogenetic mechanisms
- Immunedeficiencies and immunedepression
- Stress and immunity
Recommended text books
1) Woolf Neville Patologia Generale. Meccanismi della malattia. Idelson-Gnocchi.
2) Kumar V. A. Abbas, N. Fausto: “Robbins e Cotran: Pathologic basis of disease malattie” (2005), Elsevier Saunders, Philadelphia, USA.