Learning outcomes of the course unit
to provide the first year students with the basic concepts of classical genetics
Course contents summary
Characters segregation. Mendelian genetics. Independent assortment. Gene interaction. Chromosome theory of inheritance. Genes on X chromosome. Chromosome theory of inheritance. Chromosome structure in prokaryotes and eukaryotes. Multiple alleles. Linkage and recombination. Crossing over. crossing-over. Non-mendelian inheritance. Elements of microbial genetics. Recombination in yeast. Tetrad analysis. Recombination in bacteria, transformation, conjugation, recombination in virus. Identification of the genetic material. DNA: structure and replication. RNA structure, transcription and translation. prokaryotes and eukaryotes. RNA structure, transcription and translation. The one-gene:one-enzyme theory. Multiple alleles. Spontaneous and induced mutation. Genome, chromosome and gene mutation. Structure of the gene (Benzer); complementation; cistron. Regulation of gene expression in prokaryotes. Operon Lac: negative and positive control. Setection of spontaneous or induced mutants. Selection strategy. Mutation frequency. Molecular basis of mutations. Physical and chemical mutagens. Reversion. Suppression.
- Robert J. Brooker GENETICA analisi e principi - Zanichelli
- Griffiths, Miller, Suzuki, Lewontin e Gelbart, Genetica, Zanichelli