Learning objectives
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To provide fundamental knowledge and understanding of the nature and mechanisms of adverse and toxic effects of drugs and foreign substances.
Prerequisites
Pharmacology and pharmacotherapy
Course unit content
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General section<br />
- Fundamentals of toxicology<br />
- Absorption, distribution and excretion of toxic compounds.<br />
- Biotransformation of xenobiotics<br />
- Genetic toxicology, carcinogenicity, reproductive and developmental toxicology.<br />
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Special section<br />
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- Toxicity testing and risk assessment<br />
- Idiosyncrasy and allergic reactions, xenobiotic interactions.<br />
- Toxicology of pesticides, metals, solvents and vapors, household products, natural toxins.<br />
- Environmental toxicology: air, water and soil pollutants.<br />
- Food toxicology: food additives and contaminants.<br />
- Antidotal therapy<br />
- Toxicology of biotech products<br />
- Occupational toxicology
Full programme
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Bibliography
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CASARETT & DOULL¿S: ¿Tossicologia: fondamenti dell¿azione delle sostanze tossiche¿, Ed. EMSI, Roma.<br />
GOODMAN & GILMAN¿S: ¿The pharmacological basis of therapeutics¿<br />
GREIM&DEML: Tossicologia, Ed. Zanichelli, Bologna.<br />
DOLARA: ¿Tossicologia generale ed ambientale¿, Ed. Piccin, Padova.<br />
GHI: Tossicologia, Ed. Minerva Medica, Torino.
Teaching methods
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Assessment methods and criteria
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Other information
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