PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II
cod. 00133

Academic year 2009/10
4° year of course - Second semester
Professor
Academic discipline
Chimica farmaceutica (CHIM/08)
Field
Discipline chimico-farmaceutiche e tecnologiche
Type of training activity
Characterising
72 hours
of face-to-face activities
9 credits
hub:
course unit
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Learning objectives

<br />The course of Medicinal Chemistry II provides chemical informations about the pharmaceutical classes included in the programme, with special regard to the relationships between chemical structure and pharmaceutical, pharmacodynamic and pharmacokinetic properties. Moreover, the pourpose of the course is the study of the chemical and physicochemical properties of the drugs, the mechanism of action, the most important biotransformations and metabolic considerations, the classification of  the drugs and the nomenclature.<br /> 

Prerequisites

The course of Medicinal Chemistry II needs adequate knowledge of Organic Chemistry, Biochemistry and Physiology. The admission to the examination requires these exams and Medicinal Chemistry I.

Course unit content

<br />The course of Medicinal Chemistry II provides chemical informations about the pharmaceutical classes included in the programme.<br />Drugs acting on the Central Nervous System<br />Neurotransmmitters of the Nervous System<br />CNS Depressors<br /><br />General anesthetics<br />Sedative-Hypnotics<br />Narcotic analgesics<br />Drugs effective in the therapy of the epilepsies<br />Drugs effective for Parkinson's disease<br />Spasmolytic agents<br />Anxiolytic agents<br />Antipsychotic agents<br />Local anestetics<br />CNS Stimulants<br /><br />Analeptics<br />Psycoanaleptics and MAO-inhibitors<br />Anti-obesity drugs<br />Antidepressants<br />Hallucinogens<br />Agents for control of gastric acidity<br />Antineoplastic agents<br /><br />Alkylating agents<br />Antimetabolites<br />Antimitotic drugs<br />Antibiotics<br />Topoisomerase inhibitors<br />Ormones and antagonists<br />Antiviral agents<br /><br />Tiosemicarbazones and cyclic amines<br />Phosphonates<br />Nucleosides and acyclic nucleosides<br />Neuroaminidase inhibitors<br />Antiherpesvirus agents<br />Antiretroviral agents and protease inhibitors

Full programme

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Bibliography

<br /><br />D.A. WILLIAMS, T.L. LEMKE 'Foye's Principles of Medicinal Chemistry', Piccin, Padova. <br />E. SCHRODER, C. RUFER, R. SCHMIECHEN 'Chimica Farmaceutica, SES, Napoli. <br />D.J. ABRAHAM 'Burger's Medicimal Chemistry and Drug Discovery', Wiley, New York.

Teaching methods

The course covers about 70 hours of theoretic lessons. The examination consists in an oral test to assay the level of comprehension and the preparation of the student.

Assessment methods and criteria

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Other information

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