DRUG ANALYSIS I
Learning outcomes of the course unit
The course, divided in theoretical lessons and individual practice training, is aimed at providing the basic notions for the qualitative and quantitative determination of substances of pharmaceutical interest. In particular, during the practical training the attention will be focused on the qualitative analysis and quantitative determination of inorganic compounds.
Course contents summary
Safety and first aid procedures in the laboratory
Symbols, risk and safety phrases. Hazard chemicals handling procedures
Basic laboratory techniques and operations: solubilisation, dilution, precipitation, centrifugation, solvent extraction.
Absolute and relative density; measurement of density: densimeter, picnometer and Westphal balance.
Qualitative Inorganic Analysis
Lab equipment and instrumentation
Qualitative analysis in aqueous solution: identification of anions and cations.
Quantitative Pharmaceutical Analysis
Lab equipment and instrumentation: the analytical balance, burettes, pipettes.
Experimental error: types of errors, precision and accuracy, expression and propagation of uncertainty.
Standard and normal solutions.
Alkalimetry and acidimetry: preparation and standardization of solutions. Analysis of the titration curve: choice of the indicator.
Iodometry and iodimetry
Complexometric and chelometric titrations. EDTA: acid-base properties, effect of pH on complexation, indicators.
Araneo A. “Chimica analitica qualitativa. Metodo periodale” terza edizione, Casa Editrice Ambrosiana, Milano.
Jeffery J.H., Basset J., Mendham J., Denney R.C. “Vogel Analisi Chimica Quantitativa” Casa Editrice Ambrosiana, Milano.
Harris D.C. “Chimica Analitica Quantitativa” seconda edizione, Zanichelli, Bologna.
Practical in itinere evaluations, written and oral exam.