DRUG ANALYSIS II
cod. 06286

Academic year 2007/08
4° year of course - Second semester
Professor
Academic discipline
Chimica farmaceutica (CHIM/08)
Field
Discipline chimico-farmaceutiche e tecnologiche
Type of training activity
Characterising
108 hours
of face-to-face activities
9 credits
hub:
course unit
in - - -

Learning objectives

The course is divided into theoretical lectures and practical exercises and has been designed to provide students with knowledge on the most useful analysis methods for separation, identification and purity control of substances of pharmaceutical interest.

Prerequisites

<br />Students should have passed the Organic Chemistry examination to attend the Drug Analysis II laboratory

Course unit content

<br /><br /><br />Safety rules and elements of first aid in the chemical-pharmaceutical laboratory . <br /><br /><br />Explanation and use of the Official Italian Pharmacopoeia and of the European Pharmacopoeia. <br /><br />Drug isolation and purification techniques: extraction using solvents, crystallisation, distillation, sublimation, chromatographic methods. <br /><br /><br />Measurement of physical constants: boiling point, fusion point, specific rotatory power. <br /><br /><br />Chromatographic techniques applied to drug recognition. <br /><br /><br />Spectrophotometric methods for drug identification <br /><br /><br />Identification of organic substances: <br /><br /><br /><br /><br />preliminary tests: organoleptic examination, behaviour during combustion, solubility, qualitative elementary analysis; <br /><br /><br />recognition assays of the main functional groups and preparation of crystalline derivatives (amines, carbonyl compounds, carboxylic acids, alcohols, phenols, nitro compounds, carbohydrates, amino acids). <br /><br /><br /><br />Recognition assays of organometallic and inorganic substances of pharmaceutical interest. <br /><br /><br />Recognition of organic, organometallic and inorganic substances included in the Official Pharmacopoeia: identification reactions and purity control. Limit assays.

Full programme

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Bibliography

F. CHIMENTI: "Identificazione sistematica di composti organici" Grasso, Bologna <br />O. LIVI, A. BALSAMO: Guida pratica al riconoscimento delle sostanze iscritte nella X edizione della Farmacopea Ufficiale della Repubblica Italiana" Edizioni ETS, Pisa.<br />F. SAVELLI, A. BOIDO: "Guida all?analisi di composti di interesse farmaceutico" ? ECIG, Genova.<br />A. VOGEL: "Chimica or ganica pratica" Ambrosiana Editrice, Milano.<br />European Pharmacopoeia.

Teaching methods

<br />The courses is divided into theoretical lectures and practical activities.<br />The examination consists of a practical test (recognition of two substances included in the Official Pharmacopoeia) and an oral test covering all the topics of the course syllabus. <br /> 

Assessment methods and criteria

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Other information

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