Learning outcomes of the course unit
The course is aimed at introducing the students into the vast realm of organic chemistry, with a particular emphasis on the structure-activity relationship of the main organic compounds.
The examinations of “General and Inorganic Chemistry” and "Propaedeutic Organic Chemistry' must be passed before that of “Organic Chemistry'.
Course contents summary
Functional groups of the main organic compounds. Thermodynamic and kinetic control of organic reactions. Reaction kinetics, activation energy, catalysis. Reaction mechanisms. Radical and ionic reactions. Nucleophilic and electrophilic species. Monomolecular and bimolecular nucleophilic substitutions at saturated carbons. Monomolecular and bimolecular elimination reactions. Organometallic reagents, Grignard reagents. Electrophilic additions to alkenes. Regioselective, stereospecific, and stereoselective organic reactions. Nucleophilic addition to carbon-oxygen double bond. Acyl nucleophilic substitution. Carbon-carbon bond-forming reactions. Reactions of enolizable compounds.
Reactivity, and synthesis of the following compound classes: alkanes, cycloalkanes, alkyl halides, alkenes, alkynes, alcohols, diols, ethers, epoxides, aldehydes, ketones, carboxylic acids, acyl halides, anhydrides, esters, lactones, amides, lactams., imides, nitriles, 1,3-dicarbonyl compounds, alpha,beta-unsaturated compounds, amines.
Aromatic and heteroaromatic domain.
Structure, reactivity, and synthesis of the following compound classes: benzene, substituted benzenes and, in particular, phenols, aryl halides, and aromatic amines. Structure and reactivity of the main heteroaromatic systems.
1. J. GORZYNSKI SMITH, "Chimica Organica", McGraw-Hill.
2. W.H. BROWN, C.S. FOOTE, B.L. IVERSON, "Chimica Organica", EdiSES, III Edizione.
3. J. McMURRY, "Chimica Organica", Piccin Ed., VI Edizione.
4. S. EGE, "Chimica Organica – Struttura e Reattività", Idelson-Gnocchi Ed., II Edizione Italiana.
5. G. H. SCHMID, "Chimica Organica", Casa Editrice Ambrosiana, Milano.
The final examination consists of one written test, dealing with the resolution of simple problems on organic synthesis, and an oral colloquium.