PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II
Learning outcomes of the course unit
The course of Medicinal Chemistry II provides chemical informations about the pharmaceutical classes included in the programme, with special regard to the relationships between chemical structure and pharmaceutical, pharmacodynamic and pharmacokinetic properties. Moreover, the pourpose of the course is the study of the chemical and physicochemical properties of the drugs, the mechanism of action, the most important biotransformations and metabolic considerations, the classification of the drugs and the nomenclature.
Prerequisites
The course of Medicinal Chemistry II needs adequate knowledge of Organic Chemistry, Biochemistry and Physiology. The admission to the examination requires these exams and Medicinal Chemistry I.
Course contents summary
The course of Medicinal Chemistry II provides chemical informations about the pharmaceutical classes included in the programme.
Drugs acting on the Central Nervous System
Neurotransmmitters of the Nervous System
CNS Depressors
General anesthetics
Sedative-Hypnotics
Narcotic analgesics
Drugs effective in the therapy of the epilepsies
Drugs effective for Parkinson's disease
Spasmolytic agents
Anxiolytic agents
Antipsychotic agents
Local anestetics
CNS Stimulants
Analeptics
Psycoanaleptics and MAO-inhibitors
Anti-obesity drugs
Antidepressants
Hallucinogens
Agents for control of gastric acidity
Antineoplastic agents
Alkylating agents
Antimetabolites
Antimitotic drugs
Antibiotics
Topoisomerase inhibitors
Ormones and antagonists
Antiviral agents
Tiosemicarbazones and cyclic amines
Phosphonates
Nucleosides and acyclic nucleosides
Neuroaminidase inhibitors
Antiherpesvirus agents
Antiretroviral agents and protease inhibitors
Recommended readings
D.A. WILLIAMS, T.L. LEMKE 'Foye's Principles of Medicinal Chemistry', Piccin, Padova.
E. SCHRODER, C. RUFER, R. SCHMIECHEN 'Chimica Farmaceutica, SES, Napoli.
D.J. ABRAHAM 'Burger's Medicimal Chemistry and Drug Discovery', Wiley, New York.
Teaching methods
The course covers about 70 hours of theoretic lessons. The examination consists in an oral test to assay the level of comprehension and the preparation of the student.
