Learning outcomes of the course unit
To bring mechanisms and nature of toxic effects of drugs and xenobiotics to student's knowledge.
It is recommended to pass the Pharmacology exam or at least to achieved a good preparation on this field.
Course contents summary
First principles of toxicity
Mechanisms and tests of toxicity
ADME of toxic substance
Metabolism of xenobiotics
Cancerogenesis, teratogenesis and mutagenesis
Experimental toxicology and evaluation of toxicological risks
Idiosincrasic and allergic reactions. Interactions between xenobiotics
Metals, Solvents, Pesticides, IPA, PCOD, PCB
Toxicology of biotecnological products
Toxicology of herbal products
Poisons and antidotes
Central Nervous Sistem (CNS)
CASARETT & DOULL’S: "Tossicologia: fondamenti dell’azione delle sostanze tossiche", Ed. EMSI,
GOODMAN & GILMAN’S: "The pharmacological basis of therapeutics"
DOLARA: "Tossicologia generale ed ambientale", Ed. Piccin, Padov
ERNEST HODGSON: “Tossicologia Moderna”, EdiSES
W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.
C.L. GALLI, E. CORSINI, M. MARINOVICH “Tossicologia”, Piccin
The oral examination will be about the entire program. Students have to show to have a good comprension of principal parts of each topic.