The objectives of the course are to enable the acquisition of knowledge and understanding about etio-pathogenetic mechanisms of tumor origins and progression.
Great emphasis will be given to molecular oncology in order to allow the student to apply the knowledge gained to the understanding of the mechanisms of drug action and to acquire useful skills for future employment.To know how to communicate learned information and knowledge to experts and not experts.
Molecular and cellular oncology
Neoplasia. Definitions and nomenclature. Benign and malignant neoplasms. Grading and staging of tumors. Molecular basis of cancer. Oncogenic DNA and RNA virus. Protooncogenes, oncogenes and oncoproteins. Tumor suppressor genes. Survival and pro-apoptoticc genes. DNA repair genes. Molecular basis of multistep carcinogenesis. Angiogenesis. Tumor progression. Invasion and metastasis. Chemical carcinogenesis: initiation and promotion. Carcinogenic chemicals. Radiation carcinogenesis. Microbial carcinogenesis. Genetic predisposition to cancer. Effects of tumours on the host. Nutritional and hormonal effects. Biological basis of anti-neoplastic therapies. Study of biology, classification and therapy of breast, lung, colon cancer and melanoma.
Robbins e Cotran: Le Basi Patologiche delle Malattie. Edra IX edizione.
Pontieri-Russo-Frati: Patologia Generale.Piccin IV edizione
The topics in the program will be presented and discussed through lectures, with the aid of iconographic material, trying to involve the student so that it can be an active part of the lesson.
According to the regulation of the Italian Government and the University of Parma about the COVID-19 pandemics, the present course is realized with frontal lessons via mixed in-presence and at-distance modality. In particular, the teacher takes lessons in the classroom with the help of PC (Powerpoint slides) ; simultaneous connection of the PC to the Teams platform in streaming modality ensures connection with students not present in the classroom. Each lesson is registered and loaded in the Elly portal of the course, together with the slides.
The teacher is available for further explanations in office or by distance via Teams after e-mail appointment, or via chat on Elly platform.
The assessment of the achievement of the objectives of the course provides a multiple choice test. Through questions regarding the course content will be determined whether the student has achieved the goal of knowledge and understanding of the content and if he has reached the goal of applying the acquired knowledge.
In case the COVID-related sanitary emergence continues, the examination will proceed on the Teams platform (see the guidelines at the address: http://selma.unipr.it/).