At the end of the course, students are expected to have acquired and strengthened the knowledge and understanding of:
1) the design and the synthetic approaches aimed at the preparation of peptidomimetic scaffolds as described in the course;
2) the conjugation strategies employed to link the scaffolds to the bioactive units and the methodologies adopted in the assembly of nanoparticles.
At the end of the course, students are expected to be able to compare different synthetic and conjugation strategies to build bioactive molecular conjugates, based on their respective advantages and disadvantages.
At the end of the course, students are expected to be able to understand and critically classify scientific results and data from the literature.
Course contents summary
Examples selected from the recent literature will be presented, where small-molecule peptidomimetics or pseudopeptides were developed with the aim to target (and interfere) with specific interactions between natural ligands and their receptors involved in the progression of pathologies including cancer, inflammatory, and fibrotic diseases.
The design, synthesis and characterization of these peptidomimetic scaffolds, their use as inhibitors per se or as drug-delivery tools will be discussed.
The covalent conjugation techniques to link these scaffolds to bioactive payloads be they therapeutics or imaging-active probes, and the assembly of noncovalent nanoparticles thereof will be also described.
All the reference material, will be provided by the teacher at the beginning of the course.
The course is carried out through frontal oral lessons.
Assessment methods and criteria
Written test (short survey) on the topics presented in the course.