Exposure assessment and risk/benefit evaluation

The module will deal with methodological aspects of exposure assessment in human nutrition. Specifically, the topics will be: 1) Identification and recognition of Dietary Reference Values, Average Requirement, Population Reference Intake, Adequate Intake, Reference Intake range for macronutrients, Tolerable Upper intake Level, Suggested Dietary Target for populations. 2) Gold standards in dietary assessment for different research questions and study designs, including energy and nutrients, and issues relevant to identification, measurement and validation of biomarkers, including nutritional metabolomics. 3) Statistical methodology to estimate usual intake and uncertainty in dietary assessment. 4) Relevance to human health of nutrients and non-nutrient dietary components. 5) Definition, evaluation and applicability of nutrients and non-nutrients national and international databases. 6) Critical evaluation of the risk/benefit ratio in the framework of human nutrition.