The student will acquire specific notions on the pathogenetic role of nutritional factors in human pathology, understanding alterations at cell, tissue and organism levels. Moreover, she/he will be able to understand the molecular and cellular bases of the main nutritional disorders and to evaluate causes, mechanisms and consequences of uncorrect nutritional habits.
Nutritional stress in cell pathology. Pathophysiology of nutrition: nutritional deficiency and nutritional excess.
Food allergy and intolerance.
Nutrition and cancer.
1. Nutritional stress in cell pathology:
- Cell damage and cell death
- Storage disease: steatosis
- Cell damage from nutritional deficiency
2. Pathophysiology of nutrition:
-Hypo- and hypervitaminosis
- Trace elements deficiences
- Pathophysiology of obesity
- Role of obesity in chronic multifactorial diseases
3. Food allergy and intolerance:
- Fundamentals in immunology
- Immune tolerance
- Food allergies
- Food intolerance
- Celiac disease
4. Food and cancer:
- Molecular bases of cancer
- Chemical cancerogenesis
- Food constituents and cancer (natural compounds and additives, food processing and storage, toxins)
- Diet and cancer (lipids, ethanol, fibers, vitamins).
Students should use as a reference one of the modern textbooks of general pathology:
1. Kumar, Abbas, Fausto, Aster (Eds). Robbins e Cotran – Le Basi
Patologiche delle Malattie. 9 Edizione italiana, Elsevier Masson, 2015.
2. Mainiero, Misasi, Sorice (Eds.) Patologia Generale e Fisiopatologia
2 vol. VI edizione
3. Altucci, Berton, Moncharmont, Stivala (Eds.)
Patologia e Fisiopatologia Generale, 2 vol.
Additional references will be suggested during the lectures.
Oral interactive lectures with slides available for students on the Elly platform.
Oral examination concerning the whole Course. One of the questions will concern one of the subjects enlisted in the extended program. For additional information, see the Syllabus of the Course.