Learning outcomes of the course unit
The objectives of course are to enable the acquisition of knowledge and understanding the mechanism of proliferation and cell death, the mechanism of response to injury (inflammation, hemostasis, tissue repair), the pathogenesis of some human genetic diseases, the biological characteristics of the
tumors, as well as the essential mechanisms of the immune response.
The course allows the student to apply the knowledge and understanding gained in the professional future.
Sufficient knowledge of biology, anatomy, biochemistry and physiology are needed to address the topics of the course.
Course contents summary
The course of General Pathology is designed to provide the basic knowledge of the main causes of the human diseases. The student will acquire knowledges related to: alteration of cell growth and cell death, cellular and molecular oncology, genetic diseases, deafness, general features of acute and chronic inflammation, blood deseases and alterations of hemostasis, components of innate and acquired immune system and general features of immunopathology.
General Pathology and Physiopatology:
Cellular Pathology: Cellular alterations of growth and differentiation. Hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia. Necrosis and poptosis.
Oncology: classification and nomenclature of tumors; Benignant and malignant tumors; Tumor aetiology; Fundamentals in molecular oncology; invasivity and metastasis; pathogenesis of neoplastic diseases. Grading and staging.
The blood: composition, cells, general pathophysiology. Anemia and Thalassemia syndromes. Leukemia and lymphoma. Phases and event of the
haemostatic response. Hemorrhagic disorders; thrombosis and embolism; infarction.
Inflammation: events of acute inflammation; the exudate; types of exudate; phagocytosis; chronic inflammation and granulomas; chemical mediators
of inflammation; systemic effects of inflammation and fever; tissue repair.
Genetic disorders: mutations; monogenic diseases: examples of autosomic dominant, autosomic recessive and X-linked disorders; cytogenetic
Innate and adaptive immunity: distinction and cooperation. Antigens and Antibodies. Ag-Ab interaction. Lymphocyte receptors. The Major Histocompatibility Complex (MHC). Functional anatomy of the immune response. Lymphocyte activation and effector functions. Primary and
secondary reaction. Principles of vaccination. Immune response to infections. Hypersensitivity. Primary and secondary immunodeficencies. HIV infection.
- J. Maier “Patologia Generale e Fisiopatologia per le professioni sanitarie” II ed., McGraw-Hill
- V. Del Gobbo "Immunologia per le lauree sanitarie" IV ed., Piccin
- G.M. Pontieri “Elementi di Patologia Generale per i Corsi di Laurea in Professioni Sanitarie” III ed., Piccin
- G.M. Pontieri “Elementi di Fisiopatologia Generale per i Corsi di Laurea in Professioni Sanitarie” III ed., Piccin
The topics in the program will be presented and discussed through lectures trying to involve the student so that it can be an active part of the lesson.
Assessment methods and criteria
Learning outcomes will be verified through an oral examination. Questions on the topics relating to the course will be used to test knowledge and
understanding of the student in the scientific discipline, and her/his ability to apply such knowledge and understanding in occupational contexts. Using the knowledge also acquired in other courses the student must demonstrate knowledge and understanding about the etio-pathogenetic mechanisms of human diseases with their related essential notions of semeiotic and medical terminology.