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FORMULATION AND RELEASE OF BIOTECHNOLOGICAL DRUGS

ACADEMIC YEAR2019/2020

COD. 1004742

dati insegnamento:

DEGREE: Medical, Veterinary anf Pharmaceutical Biotechnologies

TYPE OF COURSE: SUPPLEMENTARY COMPULSORY SUBJECTS

LANGUAGE OF INSTRUCTION: Italian

LECTURERS:

NICOLI Sara

ACADEMIC YEAR: 2019/2020

YEAR OF STUDY: 2

SEMESTER: First semester

NUMBER OF CREDITS: 5

UNIT COORDINATOR: NICOLI Sara

CONTACT HOURS: 35

INDIVIDUAL WORK HOURS: 90

Learning outcomes of the course unit

The purpose of this course is to provide a general knowledge of the role of the formulation on stability, release and bioavailability pf active compounds , with a particular attention to biotech drugs. A further aim of the course is to provide the students the tools for the elaboration of the information given so as to integrate them into their knowledge. In particular at the end of the course the student shall:
-have aquired a general knowledge on pharmaceutical formulations for biotech drugs
-be able to highlight, for every formulation/administration route, potentialities, limits and impact on patient therapy
-ba able to present (orally or in writing) the topics studied in a clear way and using a correct technical language

Prerequisites

Basic knowledge of anatomy, physiology and chemistry are required

Course contents summary

The first lecture of the course presents the impact that the formulation can have on the release of the active compound and on its bioavailability, with a particular attention to the biotech drugs. Then the conventional formulations (solutions, emulsions, suspantions, solid forms) will be illustrated as well as the innovativce approaches to increase drug bioavailability

Course contents

The program is the following:
General topics: BIOAVAILABILITY, BIOPHARMACY, POLYMERS, DIFFUSION
Conventional formulations: SOLUTIONS, EMULSIONS, SUSPENSION, COLLOIDAL DISPERSIONS. LIQUIDS FOR ORAL AND PARENTERAL ROUTES, SEMISOLID FORMULATIONS, POWDERS, TABLETS, CAPSULES
INNOVATIVE FORMULATIONS and CONTROLLED RELEASE: RESERVOIR and MATRICES, OSMOTIC SYSTEMS, GASTRORETENTIVE SYSTEMS, COLON DELIVERY, MUCOADHESION, MICROPARTICLES, NANOPARTICLES, LIPOSOMES, HYDROGELS, ORAL ADMINISTRATION OF BIOTECH DRUGS
Alternative administration route: TRANSDERMAL , BUCCAL, NASAL, PULMONAR DRUG DELIVERY, ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS

Teaching methods

The course is organized with frontal lectures. The first lecture presents the rationale of the pharmaceutical formulations and highlight the background needed to deal with this course. Then, general topics such as bioavailability and bioequivalence, dissolution, diffusion, polymers, are presented. Finally, the different pharmaceutical formulations (conventional and innovative) and alternative delivery routes are explained in detail.

Assessment methods and criteria

The final examination is an oral examination and is organized so as to evaluate:
-the knowledges of the topic treated during the course
-the ability to understand and elaborate information
-the ability of applying general concepts to specific subjects
-the ability to relate the different topic studied with the knowledge aquired in the previous courses
-the pertinence of the written language (in terms of clarity and accuracy)

PARENT ACTIVITY

DRUGS AND MEDICINES

OTHER COURSES

YEAR: 1

BIOLOGICAL PHYSICAL CHEMISTRY
BIOMOLECULAR STRUCTURE AND DYNAMICS
INTERACTION DRUG-BIOMOLECULES
MOLECULAR BASIS OF DISEASES AND DEFENSIVE ANSWERS
PHARMACEUTICAL BIOCHEMISTRY
STRUCTURE AND FUNCTION OF BIOMOLECULES, CELLS AND ORGANS
STRUCTURE, DIFFERENTIATION AND FUNCTIONS OF EUKARYOTIC CELLS AND NETWORK BETWEEN ORGANS

YEAR: 2

BIOETHICS
BIOTECHNOLOGIES APPLIED TO DIAGNOSTIC
CYTODIAGNOSTICAL TECHNIQUES
DIAGNOSTIC OF ANIMAL TSE
DRUGS AND MEDICINES
ENGLISH
ETHICAL AND LEGISLATIVE ASPECTS OF BIOTECHNOLOGICAL APPLICATIONS
EXPERIMENTAL MODELS
FORMULATION AND RELEASE OF BIOTECHNOLOGICAL DRUGS
FUNCTIONAL ANATOMY OF STEM CELL NICHE
HISTOPATHOLOGICAL TECHNIQUES
Immunological techniques and parameters
INTERNSHIP AT EXTERNAL STRUCTURE
INTERNSHIP AT THE STRUCTURE OF THE UNIVERSITY
INTERNSHIP IN INTERNATIONAL MOBILITY
LEGISLATION AND PATENTS
MOLECULAR BASES OF DRUG ACTION
MOLECULAR TECHNIQUES IN GENETIC DIAGNOSTICS
REGENERATION OF DIFFERENTIATED TISSUES
REGENERATION TECHNIQUES IN VISUAL DISEASES
REGENERATIVE MEDICINE IN ENDOCRINOLOGY
TECHNIQUES FOR ORAL TISSUE REGENERATION
TECHNIQUES FOR SKIN REGENERATION

Università degli studi di Parma

via Università, 12 - I 43121 Parma

P.IVA 00308780345

tel. +390521902111

email: protocollo@pec.unipr.it

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