Learning outcomes of the course unit
the student should possess basic notions on the pathophysiology of the hematopoietic system and of the oncogenetic and infective process. The knowledge of conventional and innovative diagnostic and therapeutic strategies is also required. Moreover, the student should achieve the principles of stem cell therapy to treat hemato-oncologic diseases.
Course contents summary
basic knowledge on hematopoietic function and major hemathologic diseases
Pathophysiology of the hematopoietic system
Stem cells and bone marrow transplantation
The student should aquire the basic knowledge on the pathogenesis of following conditions:
Anemias, thrombocytopenias, neutropenia;
Monoclonal gammopathies and Multiple Myeloma;
bone marrow transplantation;
conventional and targeted anticancer therapy;
roles and functions of oncoproteins;
MAPK, AKT, STAT3, p53, p73, NF-kB PML and c-Abl signaling pathways;
cell cicle; Apoptosis; necrosis; myeloid differentiation;additive synergistic antagonistic pharmacological interactions between two or more drugs
1) Slides of the lectures; 2) Scientific papers from international bibliography.
lectures with slide show; laboratory exercises.
Assessment methods and criteria
All the slides presented during the formal lessons and laboratory exercises will be available.