PHARMACEUTICAL TECHNOLOGY LABORATORY
Learning outcomes of the course unit
The objective of the course is to give to the student the practical notions about the preparations, controls and technological properties of most common immediate release dosage forms.
The expected learning outcomes are:
1) Knowledge and understanding: knowledge of excipients, fabrication methods, of controls, of technological properties of immediate release dosage forms.
2) Applying knowledge and understanding: ability to apply, in an independent way, the knowledge acquired for the preparation of a given dosage form.
3) Communication skills: ability to use the specific language for this specialistic discipline.
4) Making judgements: the capability to face the professional responsibilities of the galenical pharmacist
5) Learning skills: capability of using the knowledge and the basic elements acquired in the conduction of the work as galenical pharmacist. Capability of upgrade, through the scientific publications in the field of pharmaceutical technology.
It is preferable to have already passed the exams of general chemistry and organic chemistry
Course contents summary
The content of the course are related to the modern and appropriate pharmaceutical compounding and galenical development, in particular with respect to the practical preparation in pharmacy and the professional responsibility of the pharmacist.
The first part of the course will focus on the fundamentals of metrology and of the unit operations. In the second part the student will learn how to compound the different dosage forms
In agreement with the Pharmacopoeial requirements
• Legal issues concerning the preparation, packaging and pricing of galenical preparation according to the Italian Pharmacopeia
• Preparation and characterization of conventional dosage forms:
o Oral powders
o Topical powders
o Liquid preparations for oral use
o Liquid preparation for topical use
o Topical semisolid dosage forms
o Vaginal preparations
o Rectal preparations
ENRICO RAGAZZI, «Galenica pratica, formulazione e tecnologia», Libreria Internazionale Cortina Padova
FRANCO BETTIOL, «Manuale delle preparazioni galeniche», Tecniche Nuove
Farmacopea Ufficiale XII Ed.
PAOLO COLOMBO, et al. Principi di Tecnologia Farmaceutica, Seconda Ed.Casa Editrice Ambrosiana, Milano (2015)
H. ANSEL, S. STOCKTON PRINCIPI DI CALCOLO FARMACEUTICO A cura di Gaia Colombo, Alessandra Rossi, Paola Russo, Fabio Sonvico Casa Editrice EDRA
It is also advised the reading of:
Farmacopea Ufficiale XII Ed.
-Medicamenta, Cooperativa Farmaceutica Milano, VII ED. 1992
International Journal of Pharmaceutical compounding
The course will be carried out through frontal lessons (2CFU) during which the fundamentals, the theoretical and practical aspects of the compounding will be presented and discussed.
3 CFU will be devoted, then, to the practical preparation of different dosage forms with particular emphasis to the physico- chemical as well as legal aspects of the different operations
Assessment methods and criteria
To acquire the final grade of the exam, the student must show to be have learned and to be able to use the basic concepts of each subject. In particular he/she should:
a) pass a practical exam at the end of practical works (Module of Laboratorio di Tecnologia Farmaceutica, weight 40% of the overall grade);
b) pass an exam (either oral and written), during the official dates established by the Dipartimento di Farmacia (both modules, weight 60% of the overall grade).
The grade, expressed in thirtieths, will be based on the following criteria:
1. knowledge and comprehension (theoretical and practical) capability of the subjects studied;
2. making judgements ability
3. communication skills and appropriate use of the technical language;
4. ability to learn.