PHYSICS APPLIED TO MEDICINE
Learning outcomes of the course unit
The module of "Physics Applied to Medicine" has been designed to convey knowledge and understanding of basic physics principles, providing an introductory basis for other disciplines including Chemistry, Biology, Physiology, Biochemistry, etc., that rely on the physical phenomenology on make frequent use of it.
The course will also provide the conceptual basis for understanding a number of major technologies that with increasing frequency are used in medicine, such as: centrifuges, endoscopes, microscopes, transducers for ultrasound equipment, laser systems, radiology equipment and NMR, radiation detectors, etc. In this sense, the module also aims to develope the students' attitude towards independent study and continuing education on the application of physical techniques to diagnosis and therapy in medicine.
As its final, but perhaps most important, goal, the course has been designed to stimulate students to become more familiar with certain common concepts, that are not always sufficiently explained in previous studies, such as: mechanical action between bodies in contact, exertion and energy in action, dynamic aspects resulting from elastic force and impact, friction and thermal and thermodynamic aspects, static and dynamic properties of gaseous and liquid fluids, light and its manifestations, also in relation to the structure of the eye and its physical defects, fundamentals of electrical, magnetic and nuclear phenomena, the laws that govern potential and current, electromagnetic and nuclear radiation, perturbations induced in means passed through and aspects of detection and control.
Course contents summary
The first part of the module of "Physics Applied to Medicine" will deal with the definition of physical quantities and measure systems and units.
The module will then tackle the fundamental principles of mechanics, fluid dynamics, electromagnetism, thermology, waves and optics.
Applications and consequences on human body physiology and medicine will be stressed. In particular, deeper insights will be provided into biomechanics, blood circulation, the use of radiations in diagnosis and therapy.
Physical quantitites and their measurement: Measurement of a physical quantity - Dimensions and units – Errors - Vector quantities.
Fundamentals of dynamics: Principles of dynamics - Energy, work and power - Weight force - Theorem of the kinetic energy - Conservative force fields - Potential energy - Conservation of mechanical energy - Center of mass and its properties -Conservation of the quantity of motion - Moment of force - Overview of rigid body motion - Levers and the human body –Elastic phenomena, Hooke’s law and elasticity modules - Flexure and torsion - Elasticity of blood vessels and bones.
Waves and acoustics: Wave motion, wave equation and characteristic parameters - Interference -
Diffraction and Huyghens principle - Sound and its characteristics - Intensity, sensation, Weber-Fechner law - Doppler effect - Ultrasound and its application in the biomedical field.
Hydrostatics and hydrodynamics: Pressure - Laws of Stevin, Pascal and Archimedes - Atmospheric pressure and Torricelli’s barometer - Arterial pressure and its measurement - Surface tension and Laplace’s formula - Capillarity and Jurin’s law - Gaseous embolism - Pipe flow capacity - Ideal liquid and Bernouilli’s theorem -Implications for blood flow - Real liquids and viscosity - Laminar motion and Poiseuille’s theorem - Hydraulic resistance - Stokes’ equation and sedimentation speed - Turbulent regime and Reynolds number - Overview of cardiac work.
Thermology: Thermal dilation -Temperature and heat - Laws of gas and absolute temperature - Equation of state of ideal gases and approximation for real gases - Overview of the kinetic theory of gases - Specific heats –Change of state and latent heat - Heat propagation mechanisms.
Optics: Reflection and refraction - Total reflection and optical fiber - Optical system, focus and dioptric power - Spherical diopter - Thin lenses and image construction - Compound microscope - Resolution strength - The eye as a dioptric system - Principal ametropies of the eye and their correction using lenses - Wave theory of light - Laser light.
Electricity, magnetism and electrical current: Electrical charges and Coulomb’s law - Electrical field - Work of the electrical field and electrostatic potential - Dipolar field - Overview of muscle fiber and electrocardiogram - Gauss’s theorem and its applications - Current intensity - Overview of the electronic structure of insulators, metallic conductors and semiconductors - Ohm’s law - Series and parallel resistors – Electromotive force - Thermal effect of current - Electrical conduction in liquids - Passing of current in the human body -Thermoionic and photoelectric effects - Magnetic field and its action on current and magnets - Alternating voltage and current - Impedance - Electromagnetic waves.
Radiation: Notes on the structure of the atom and nucleus - Unstable isotopes and alpha, beta, gamma radiation - Law of radioactive decay and half-life - iomedical applications of radioisotopes - X-rays (production, properties and absorption mechanisms in the matter) - Radiological image - Overview of computerised axial tomography (CAT), PET, SPECT and radiofrequency (NMR) imaging techniques- Overview of radiation safety.
Bersani, Bettati, Biagi, Capozzi, Feroci, Lepore, Mita, Ortalli, Roberti, Viglino, Vitturi:
Fisica biomedica, Ed. Piccin Nuova Libraria (Padova).
Scannicchio: Fisica Biomedica, Ed. EdiSES (Napoli).
Celasco: Lineamenti di Fisica Medica, Ed. E.C.I.G. (Genova).
During classroom lectures, the topics contained in the program of the module will be illustrated and commented. Emphasis will be posed on the applications to biology and medicine of basic physics principles, with examples of how such principles can lead to quantitative predictions on physiological and pathological phenomena.
In selected cases, the demontration of basic physics principles will be illustrated, with the aim to introduce the students to the practice of logical thinking and experimental approach.
On a voluntary basis, the students will be given the possibility to take part to laboratory activities, aiming at the experimental validation of fundamental physics laws.
Assessment methods and criteria
The achievement of the objectives of the module will be assessed through a written exam, mainly consisting in open questions on the topics of the course. This will allow to ascertain the knowledge and the understanding of both the theoretical bases and their consequences in biology and medicine.
The written exam will include the resolution of problems, to assess the achievement of the ability to apply the acquired knowledge to a simulated biological or medical situation.
All parts of the written exam will be equally weighted in the final evaluation.