Learning outcomes of the course unit
Through class attendance and through self-study, the student will acquire the following skills
Knowledge and understanding: The student will demonstrate knowledge of the physico-chemical bases that regulate the operation of nuclear receptors and membrane; to understand the mechanisms through which small molecules activate or block nuclear or membrane receptors
Applying knowledge and understanding: The student must show to be able to synthesize their knowledge, their ability to analyze and understand the structure-activity relationships for classes of drugs through devising and sustaining critical arguments in the field of medicinal chemistry, proving to be able to have a professional approach to discipline
In addition, the teaching aims to achieve autonomy of judgment and Communicative Abilities.
Making judgments: Students will be able during the lessons, to interact with the themes suggested by the teacher and, even with the help of the recommended texts and teaching materials, be able to make independent judgments
Communication skills: The student must be able to clearly and critically present the results of their individual calculations, demonstrating knowledge of research topics carried out during the program
Organic Chemistry , Medicinal Chemistry , Biochemistry , Physiology , Pharmacology
Course contents summary
1) Nuclear receptors
- molecular basis
- definition of a steroid hormone
- nomenclature and chemical structure of steroid hormones
- biosynthesis of steroid hormones
- mechanism of action of steroid hormones
3) Female sex hormones
4) Male sex hormones
5) Hyperlipoproteinemia and cardiovascular disease
- the cholesterol and other blood lipids
- cholesterol biosynthesis
6) HMG - CoA reductase inhibitors ( statins )
7) Medicines to treat diabetes
- type 1 diabetes
- type 2 diabetes
8) Oral hypoglycemic
1) Gragam L. Patrick ,
III edition Edises
2) PPT presentation made by the teacher are part of the reference text. They will be made available at the end of the lesson in Elly platform
The course will be conducted through lectures . Each lesson is a teaching module unit , in which , for each topic , are given to the student the foundation for acquiring knowledge and understanding , and to apply the knowledge and understanding to the problem treated in the unit of learning module.
besides the PPT presentations made by the teacher, also videos of the lesson will be made available on Microsoft Stream during all the last of the course.
scientefic lecterature regarding the topic of interest will be made as well available on Elly platform, before or after the lesson.
Assessment methods and criteria
Through an oral exam it will be ' verified that the student has successfully acquired the knowledge and understanding and the ability to apply knowledge and understanding of at least three topics covered in the course . In addition , it will be ' evaluated the independence of judgment and communication skills . The examination is only passed if the student will demonstrate a correct acquisition of skills . The vote will be formed for 30% of knowledge and understanding , 30 % of application of knowledge and understanding , 20 % of independent judgment and 20 % of communication skills .
Regarding point A) the student should be able to describe the molecular interaction responsible for the binding of the molecules to the nuclear receptor.
Regarding point B) the student should be able to write correctly the structure of the molecules and describe the structure activity relationships. the student should be to critically describe the synthesis of the molecules of interest.
Regarding point C) the student should be able to demosntrate the learning of the relationships between the molecules and their therapeutic action and make connections among different pathologies.
Regarding point D) The student should be able to associate to the chemical structures and the syntheses the proper language which is pertinent to the chemistry environment.