The course is divided into theoretical lectures and practical exercises and has been designed to provide students with knowledge of qualitative and quantitative analysis. In particular, during the practical training, attention will be focused on the acquisition of the basic laboratory techniques and on the safety procedures in lab. Another fundamental goal of the course will be to acquire the ability of communicating information, and to solve problems that could arise during the lab.
Students must have passed the General and Inorganic Chemistry examination to attend the Drug Analysis I laboratory.
Course contents summary
The first part of the program involves the study of the safety rules fundamental for work in a medicinal-chemistry laboratory. Moreover, laboratory equipment and basic laboratory techniques and operations (solubilisation, dilution, precipitation, centrifugation, filtration) will be explained.
The second part of the course concerns the Qualitative Analysis: identification of anions and cations.
The second part of the course concerns the Quantitative Analysis: experimental error (types of errors, precision and accuracy), volumetric analysis, sampling, standard and normal solutions, choise of indicator, titrations (alkalimetry and acidimetry, redox, complexometric, potentiometric), quantitative analysis of active pharmaceutical ingredients by UV-VIS spectroscopy.
¥ Hage, D.S.; Carr, J.D. Chimica Analitica e Analisi Quantitativa, PICCIN;
¥ Savelli, F.; Bruno, O. Analisi Chimico Farmaceutica, PICCIN.
¥ Cavrini V.; Andrisano V. Principi di Analisi Farmaceutica, ESCULAPIO
The course is divided into theoretical lectures and practical activities. To ensure a better participation of the students and their safety, three different laboratory shifts have been set, each with a different teacher.
Assessment methods and criteria
The final exam consists of practical tests and of a written test covering all the topics of the course. During laboratory tests the student must be able to recognize an unknown inorganic substance and to dosage a known drug. To pass the exam, only one mistake is allowed in the search for the unknown ions while, for the quantitative analysis test, it is necessary to maintain the error within 1%. Written exam is structured with open questions, each one with a predetermined score.
To achieve the objectives of the course, students will attend laboratories equipped with the instrumentation useful for the qualitative and quantitative analysis of compounds of pharmaceutical interest.