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MEDICINAL PRODUCTS FOR ADVANCED THERAPY

ACADEMIC YEAR2017/2018

COD. 1000255

dati insegnamento:

DEGREE: MEDICAL, VETERINARY AND PHARMACEUTICAL BIOTECHNOLOGIES

TYPE OF COURSE: SUPPLEMENTARY COMPULSORY SUBJECTS

LANGUAGE OF INSTRUCTION: Italian

LECTURERS:

BETTINI Ruggero

ACADEMIC YEAR: 2017/2018

YEAR OF STUDY: 1

SEMESTER: Second semester

NUMBER OF CREDITS: 2

UNIT COORDINATOR: BETTINI Ruggero

CONTACT HOURS: 14

INDIVIDUAL WORK HOURS: 36

Learning outcomes of the course unit

The main goal of the course is the understanding of the chemistry and physics of natural and sinthetic polymers used in tissue engineering and drug delivery.

Prerequisites

General knowledge of inorganic and organic chemistry are required

Course contents summary

Chemistry of natural and synthetic polymers used in biomedical applications, in particular for the production of tridimensional biocompatible systems.
The course provides also theoretical knowledge on drug release mechanisms of biologically active substances from polymeric matrices.

Course contents

• Polymer definition and classification.
• Linear and crosslinked polymers, method of polymerisation and crosslinking.
• Polymer molecular weight and its determination.
• Solid state of polymers, crystalline and amorphous structure.
• Glassy and rubbery state, transition temperature.
• Polymers in solution.
• Natural and synthetic polymers used in biomedicine.
• Tridimensional structure of polymeric scaffolds.
• Chemical modification of polymers.
• Solid state manipulation.
• Physico-chemical characterisation of tridimesional polymeric structures, and films.
• Polymeric scaffolds as drug delivery systems.
• Drug release kinetics from matrix systems.

Teaching methods

The course will be carried out through frontal lessons in which the fundamentals of polymer chemistry will be presented and discussed, as well as well as the solid state chemistry and the behaviour in solution.
In the second part of the course the concepts presented in the first one will be applied to the manipulation of the polymers, mostly of natural origin, for the preparation of hydrogels and tridimensional structures for tissue repair.

Assessment methods and criteria

Oral exam consisting in questions aiming at verifying the comprehension of the studied topics and the competences acquired. The results will be expressed in 30th.

PARENT ACTIVITY

BIOMATERIALS AND BIOCOMPATIBLE SYNTHETIC MATERIALS

OTHER COURSES

YEAR: 1

BIOLOGICAL BASES AND TECHNIQUES FOR REGENERATION AND REPAIR
BIOLOGICAL MECHANISMS OF REGENERATION AND REPAIR
BIOMATERIALS AND BIOCOMPATIBLE SYNTHETIC MATERIALS
BIOPROTESIS
HEMATOPOIETIC STEM CELLS: BIOLOGY AND CLINICAL APPLICATIONS
MEDICINAL PRODUCTS FOR ADVANCED THERAPY
MYOCARDIAL REGENERATION AND NEOANGIOGENESIS
OSTEOGENESIS AND CONDROGENESIS: MODELS OF BIOCOMPATILITY IN VIVO AND IN
OSTEOGENESIS AND CONDROGENESIS: MODELS OF BIOCOMPATILITY IN VIVO AND IN

Università degli studi di Parma

via Università, 12 - I 43121 Parma

P.IVA 00308780345

tel. +390521902111

email: protocollo@pec.unipr.it

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