BASIC CONCEPTS OF MEDICAL PHARMACOLOGY (FR)
cod. 1002374

Academic year 2018/19
3° year of course - Second semester
Professor
- Lucio Guido COSTA - Enzo POLI
Academic discipline
Farmacologia (BIO/14)
Field
Fisiopatologia, metodologia clinica, propedeutica clinica e sistematica medico-chirurgica
Type of training activity
Characterising
21 hours
of face-to-face activities
3 credits
hub:
course unit
in ITALIAN

Learning objectives

Knowledge and understanding of pharmacokinetics and pharmacodynamics fundamentals

Prerequisites

Knowledge of basic disciplines (anatomy, physiology, istologybichemistry, general pathology).

Course unit content

General Pharmacology

Full programme

General pharmacology, cellular and molecular. pharmacology. Branches of pharmacology. Concept of drug,
Drug development: preclinical phase with toxicological tests, clinical Phases, pharmacovigilance.
Pharmacokinetics: absorption, distribution, biotransformation and elimination of drugs; clearance; half-life; bioavailability; pharamceutical forms and routes of drug administration.
Pharmacodynamics: mechanisms of action of drugs; Drug-receptor interaction; affinity, potency, efficiency; Drugs acting as agonists and/or antagonists; dose-response curve. Drugs acting at ion channels, carriers, DNA. Enzyme inhibitors.
Principles of interaction between drugs.
Modification of the response to drugs: tachyphylaxis, tolerance, drug resistance. Pharmacogenetics and idiosyncratic responses.
Drug toxicity.

Bibliography

Rang, Dale et al., Pharmacology - Elsevier;
Katzung: Pharmacology (last ed.);
Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)

Teaching methods

Classroom lectures

Assessment methods and criteria

Oral exam (after the second part of the course)

Other information

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