Learning outcomes of the course unit
The objectives of the General Pathology course are to enable the
acquisition of knowledge and understanding the mechanism of
proliferation and cell death and their alteration in the biology of tumours,
the pathogenesis of some human genetic and metabolic diseases with
their related essential notions of semeiotic and medical terminology, the
mechanism of innate and specific immune system, the pathogenesis of
the main immunopathologic diseases, the ABO blood and the rhesus (Rh)
blood groups, and problems related to blood transfusion.
Course contents summary
General alteration of growth and death, cellular and molecular and
cellular oncology. Genetic and metabolic diseases and general
Blood and hematopoiesis and components of innate and acquired
immune system. General features of acute and chronic inflammation and
immunopathology. Immunoemathology and transfusional medicine.
Cellular Pathology and Physiopathology
Cellular alterations of growth and differentiation. Necrosis and apoptosis.
Atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia.
Definition, nomenclature, and biological properties of benign and
malignant neoplasms. Molecular basis of cancer. Metastatic
Blood and Hematopoiesis. Stem cells. Leukemia and lymphoma. Anemias.
Transmission patterns of single-gene disorders. Examples of genetic
disease. Chromosomal alterations.
Atherosclerosis, trombosis, angina and myocardial infarction.
General features of acute and chronic inflammation Vascular changes,
cellular events and chemical mediators. Inflammatory exudate and
systemic effects. Fever and hyperthermia. Chronic inflammation:
classification, cytological features and granuloma. Tissue repair.
Diabetes mellitus and atherosclerosis.
Innate immunity. Acquired immunity. The structural and functional
aspects of Antibodies. T and B lymphocytes and their receptors. The
Major Histocompatibility System (MHC). Activation of B and T
lymphocytes. Vaccinations. Hypersensitivity. Transplantation.
ABO blood groups and serum antibodies. The rhesus (Rh) blood groups.
Other blood groups. Haemolytic disease of the newborn.
Parola M. “Patologia Generale” EDISES
Pontieri G.M. “Elementi di Patologia Generale” III edizione PICCIN
Pontieri G.M. Patologia generale e Fisiopatologia generale. III edizione
The topics in the program will be presented and discussed through
lectures trying to involve the student so that it can be an active part of
Assessment methods and criteria
Learning outcomes will be verified through an oral examination.
Questions on the topics relating to the course will be used to test
knowledge and understanding of the student in the scientific discipline,
and her/his ability to apply such knowledge and understanding in
occupational contexts. Using the knowledge also acquired in other
courses the student must demonstrate knowledge and understanding
about the etio-pathogenetic mechanisms of human diseases with their
related essential notions of semeiotic and medical terminology.